ArticleNature neuroscience2022
Fiber photometry in striatum reflects primarily nonsomatic changes in calcium.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 96 citations in OpenAlex.
- Article
- Striatal pathways dissociably control action counting and goal-directed steering.Nature neuroscience · 2026Article
- Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior.Science advances · 2026Article
- Learning dynamically regulates stimulus discrimination of ventral striatal D1 receptor expressing neurons.Science advances · 2026Article
- Stars2Cells: Astrometric Tracking of Neurons Across Imaging Sessions.bioRxiv : the preprint server for biology · 2026Article
- Anterior Cingulate Cortex Mediates State-Dependent Prioritization of Distressed Conspecifics.Brain sciences · 2026Article
- Inherited input and local transformations shape the spatiotemporal organization of pathway specific striatal signals for motivated behavior.bioRxiv : the preprint server for biology · 2026Article
- Uncovering phenotypic diversity and cell-type-specific prefrontal cortex calcium dynamics in rat fentanyl self-administration.bioRxiv : the preprint server for biology · 2026Article
- Automated device for permitting free movement during simultaneous photometry and electrophysiology in mice.Nature methods · 2026Article
- Multifiber Array-Based Photometry System for Multiregional Functional Mapping in the Mouse Brain.The European journal of neuroscience · 2026Article
- Article
- Article
- Revealing abrupt transitions from goal-directed to habitual behavior.Nature communications · 2026Article
- Protocol to build open-source Discrimin8 maze to study discrimination of reward-context associations in mice during open-field foraging.STAR protocols · 2026Article
- A dual-color miniature endoscope for calcium imaging in behaving mice.bioRxiv : the preprint server for biology · 2026Article
- Learning dynamically regulates stimulus discrimination of ventral striatal D1 receptor expressing neurons.bioRxiv : the preprint server for biology · 2025Article
- Striatal Pathways for Action Counting and Steering.bioRxiv : the preprint server for biology · 2025Article
- Review
- Progress toward Multianalyte Neurochemical Detection: Techniques and Applications.ACS chemical neuroscience · 2025Review
- Flexible updating of reward and punishment contingencies by VTA GABA neurons.Current biology : CB · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Fiber photometry enables recording of population neuronal calcium dynamics in awake mice. While the popularity of fiber photometry has grown in recent years, it remains unclear whether photometry reflects changes in action potential firing (that is, 'spiking') or other changes in neuronal calcium. In microscope-based calcium imaging, optical and analytical approaches can help differentiate somatic from neuropil calcium. However, these approaches cannot be readily applied to fiber photometry. As such, it remains unclear whether the fiber photometry signal reflects changes in somatic calcium, changes in nonsomatic calcium or a combination of the two. Here, using simultaneous in vivo extracellular electrophysiology and fiber photometry, along with in vivo endoscopic one-photon and two-photon calcium imaging, we determined that the striatal fiber photometry does not reflect spiking-related changes in calcium and instead primarily reflects nonsomatic changes in calcium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.