ArticleNature neuroscience2022
Behaviorally relevant decision coding in primary somatosensory cortex neurons.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
- A cortical output channel for perceptual categorization.Science advances · 2026Article
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- Neural correlates of perceptual decision-making in the primary somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Diminished Signal-to-Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An intralayer microcircuit in the temporal association cortex underlies sensory-induced escape in mice.Nature communications · 2026Article
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- Triggering action potentials of a single neuron by multiphoton excitation elicits visually guided behavior.Nature communications · 2026Article
- Secondary Somatosensory Cortex Is Required for Learning but Not Execution of a Tactile Discrimination.The European journal of neuroscience · 2026Article
- An adaptive and flexible role for primary sensory cortex.Nature neuroscience · 2026Review
- Coordinated cellular architecture reveals weakened cortical structure-behavior coupling in normal aging.Frontiers in aging neuroscience · 2026Article
- Brain-wide coordination of internal signals during decision-making.bioRxiv : the preprint server for biology · 2025Article
- Context-dependent activation of V1 parvalbumin interneurons enhances visual discrimination.PLoS biology · 2025Article
- A real-time all-optical interface for dynamic perturbation of neural activity during behavior.Cell reports methods · 2025Article
- Linear and categorical coding units in the mouse gustatory cortex drive population dynamics and behavior in taste decision-making.bioRxiv : the preprint server for biology · 2025Article
- Feature-specific inhibitory connectivity augments the accuracy of cortical representations.bioRxiv : the preprint server for biology · 2025Article
- Article
- Reveal the mechanism of brain function with fluorescence microscopy at single-cell resolution: from neural decoding to encoding.Journal of neuroengineering and rehabilitation · 2025Review
- Quantitative dynamics of neural uncertainty in sensory processing and decision-making during discriminative learning.Experimental & molecular medicine · 2025Article
- Article
- Intra-somatosensory cortical circuits mediating pain-induced analgesia.Nature communications · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
Primary sensory cortex is thought to process incoming sensory information, while decision variables important for driving behavior are assumed to arise downstream in the processing hierarchy. Here, we used population two-photon calcium imaging and targeted two-photon optogenetic stimulation of neurons in layer 2/3 of mouse primary somatosensory cortex (S1) during a texture discrimination task to test for the presence of decision signals and probe their behavioral relevance. Small but distinct populations of neurons carried information about the stimulus irrespective of the behavioral outcome (stimulus neurons), or about the choice irrespective of the presented stimulus (decision neurons). Decision neurons show categorical coding that develops during learning, and lack a conclusive decision signal in Miss trials. All-optical photostimulation of decision neurons during behavior improves behavioral performance, establishing a causal role in driving behavior. The fact that stimulus and decision neurons are intermingled challenges the idea of S1 as a purely sensory area, and causal perturbation suggests a direct involvement of S1 decision neurons in the decision-making process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.