ArticleNature communications2022
Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 167 citations in OpenAlex.
- Design rules for externally triggered drug uncaging under optical and radiolytic regimes.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2026Review
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- Synthesis of radioafterglow nanoprobes for deep-tissue imaging of hydrogen peroxide.Nature protocols · 2026Review
- Landscape and evolutionary trends of nanotechnology in cancer radiosensitization.Discover nano · 2026Review
- Long-Acting Dynamic Therapy Using X-Ray Activated Organic Nanoparticles for Afterglow Imaging Guided Deep Tumor Treatment.Angewandte Chemie (International ed. in English) · 2026Article
- Recent Advances of Organic Room Temperature Phosphorescence for Biological Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Nanomaterials reshaping cancer radiotherapy: Radiosensitization mechanisms, delivery and theranostic platforms, multimodal synergy, and clinical translation strategies.Materials today. Bio · 2026Review
- Intermolecular Aggregation-Induced Delayed Fluorescence Scintillators for Ultrahigh-Resolution X-Ray Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Liposome-Based Photodynamic Therapy for Breast Cancer: Innovations in Targeted Delivery, Combination Strategies, and Clinical Translation.International journal of molecular sciences · 2026Review
- Rare-earth cerium-coordinated ICG nanoprobe for tumor hypoxia relief and intensified photodynamic therapy.Materials today. Bio · 2026Article
- Polyphosphoester-Based Nanocarriers for Combined X-Ray-Induced Photodynamic Therapy and Immunotherapy.Pharmaceutics · 2026Article
- Simulation-Based X-Ray Spectrum Optimization for Dose Enhancement in X-Ray-Induced Photodynamic Therapy with NaLuFBioengineering (Basel, Switzerland) · 2026Article
- Host-Guest Doping Enables Room Temperature Phosphorescence from Triarylboranes.Angewandte Chemie (International ed. in English) · 2026Article
- Sunlight PDT leveraging NIR-II nanospray: painless, hemostatic, anti-inflammatory therapy towards diabetic wound infections.National science review · 2026Article
- Illumination of Targeting Nanotherapeutics with Precision Eyes: From Optical to Radio-nanotheranostics.Theranostics · 2026Review
- Emerging Nanoplatforms are Effective Against Tumor Hypoxia.International journal of nanomedicine · 2026Review
- A Bromobenzoyl Pyridine Photosensitizer with Suppressed Phosphorescence for Efficient ROS-Based Photodynamic Therapy.Journal of fluorescence · 2025Article
- Molecular afterglow imaging for biomedical applications.Nature materials · 2025Review
- Unlocking radioluminescence in copper cyclic trinuclear complexes.Science advances · 2025Article
- Organic AIE Nanoradiosensitizer Potentiates X-Ray Triggered Continuous Reactive Oxygen Species Generation for Potent Cancer Radioimmunotherapy.Advanced materials (Deerfield Beach, Fla.) · 2025Article
Corrections and comments
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Authors and funding
28 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
X-ray-induced photodynamic therapy utilizes penetrating X-rays to activate reactive oxygen species in deep tissues for cancer treatment, which combines the advantages of photodynamic therapy and radiotherapy. Conventional therapy usually requires heavy-metal-containing inorganic scintillators and organic photosensitizers to generate singlet oxygen. Here, we report a more convenient strategy for X-ray-induced photodynamic therapy based on a class of organic phosphorescence nanoscintillators, that act in a dual capacity as scintillators and photosensitizers. The resulting low dose of 0.4 Gy and negligible adverse effects demonstrate the great potential for the treatment of deep tumours. These findings provide an optional route that leverages the optical properties of purely organic scintillators for deep-tissue photodynamic therapy. Furthermore, these organic nanoscintillators offer an opportunity to expand applications in the fields of biomaterials and nanobiotechnology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.