Evidence map›Paper›PMID 36041998›Full record

ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2022

High depression symptomatology and mental pain characterize suicidal psychiatric patients.

Maurizio Pompili, Marco Innamorati, Denise Erbuto, Mario Luciano, Gaia Sampogna, Giovanni Abbate-Daga, Stefano Barlati, Claudia Carmassi, Giovanni Castellini, Pasquale De Fazio and 16 more

Abstract read
In one paragraph

Article in European psychiatry : the journal of the Association of European Psychiatrists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Demographic and clinical baseline characteristics from the Spanish SURVIVE prospective cohort study on suicide attempts.European psychiatry : the journal of the Association of European Psychiatrists · 2026
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  18. On mental pain and suicide risk in modern psychiatry.Annals of general psychiatry · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Maurizio PompiliDepartment of Neurosciences, Mental Health, and Sensory Organs, Faculty of Medicine and Psychology, Suicide Prevention Centre, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-1886-4977
Marco InnamoratiDepartment of Human Sciences, European University of Rome, Rome, Italy.
Denise ErbutoDepartment of Neurosciences, Mental Health, and Sensory Organs, Faculty of Medicine and Psychology, Suicide Prevention Centre, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-6403-7254
Mario LucianoDepartment of Psychiatry, University of Campania "L. Vanvitelli", Naples, Italy.ORCID 0000-0002-4338-1371
Gaia SampognaDepartment of Psychiatry, University of Campania "L. Vanvitelli", Naples, Italy.
Giovanni Abbate-DagaEating Disorders Center, Department of Neuroscience, University of Turin, Turin, Italy.ORCID 0000-0002-5826-5664
Stefano BarlatiDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.ORCID 0000-0002-1784-3915
Claudia CarmassiPsychiatric Clinic, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0002-3662-8073
Giovanni CastelliniPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Pasquale De FazioPsychiatric Unit, Department of Health Sciences, University Magna Graecia, Catanzaro, Italy.
Giorgio Di LorenzoDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0002-0576-4064
Marco Di NicolaDepartment of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0001-7457-0426
Silvia FerrariDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0001-7929-4520
Arianna GoracciDepartment of Molecular Medicine, University of Siena, Siena, Italy.
Carla GramagliaDepartment of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.
Giovanni MartinottiDepartment of Neuroscience, Imaging and Clinical Sciences, University "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy.
Maria Giulia NanniDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.ORCID 0000-0002-1085-4339
Massimo PasquiniDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-3959-8137
Federica PinnaSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Nicola PoloniDivision of Psychiatry, Department of Medicine and Surgery, University of Insubria, Varese, Italy.ORCID 0000-0001-5173-087X
Gianluca SerafiniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, Psychiatry Section, University of Genoa, IRCCS San Martino, Genoa, Italy.
Maria SignorelliDepartment of Clinical and Experimental Medicine, AOU Policlinico Hospital, University of Catania, Catania, Italy.ORCID 0000-0001-5835-4176
Alfonso TortorellaDepartment of Psychiatry, University of Perugia, Perugia, Italy.ORCID 0000-0002-8095-2305
Antonio VentriglioDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Umberto VolpeUnit of Clinical Psychiatry, Department of Neurosciences/DIMSC, School of Medicine and Surgery, Polytechnic University of Marche, Ancona, Italy.ORCID 0000-0001-9166-7609
Andrea FiorilloDepartment of Psychiatry, University of Campania "L. Vanvitelli", Naples, Italy.ORCID 0000-0002-6926-0762

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSymptoms of depression are transdiagnostic heterogenous features frequently assessed in psychiatric disorders, that impact the response to first-line treatment and are associated with higher suicide risk. This study assessed whether severe mental pain could characterize a specific phenotype of severely depressed high-risk psychiatric patients. We also aimed to analyze differences in treatments administered.

methods2,297 adult patients (1,404 females and 893 males; mean age = 43.25 years, SD = 15.15) treated in several Italian psychiatric departments. Patients were assessed for psychiatric diagnoses, mental pain, symptoms of depression, hopelessness, and suicide risk.

resultsMore than 23% of the patients reported high depression symptomatology and high mental pain (HI DEP/HI PAIN). Compared to patients with lower symptoms of depression, HI DEP/HI PAIN is more frequent among females admitted to an inpatient department and is associated with higher hopelessness and suicide risk. In addition, HI DEP/HI PAIN (compared to both patients with lower symptoms of depression and patients with higher symptoms of depression but lower mental pain) were more frequently diagnosed in patients with personality disorders and had different treatments.

conclusionsPatients reporting severe symptoms of depression and high mental pain presented a mixture of particular dangerousness (high trait hopelessness and the presence of suicide ideation with more frequency and less controllability and previous suicide behaviors). The presence of severe mental pain may act synergically in expressing a clinical phenotype that is likewise treated with a more complex therapeutic regime than that administered to those experiencing symptoms of depression without mental pain.

Indexed as

Mental DisordersSuicidal IdeationAffectDepressionFemaleHumansItalyMaleRisk FactorsDepression symptomatologyhopelessnessmental painpsychopharmacological medicationssuicide behaviors and ideation

Identifiers

PMID36041998
PMCPMC9491079

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.