Evidence map›Paper›PMID 36041950›Full record

ReviewTrends in immunology2022

Sterols in asthma.

Mireia Guerau-de-Arellano, Rodney D Britt

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mireia Guerau-de-ArellanoSchool of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, The Ohio State University, Columbus, OH, USA. Electronic address: mireia.guerau@osumc.edu.
Rodney D BrittCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Nationwide Children's Hospital · USThe Ohio State University Wexner Medical Center · US

Funding

Airway Structural Cells and Corticosteroid Resistance in AsthmaR01HL155095 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BRITT, RODNEY · 2021 to 2025
$2.5M
Epigenetic modulation of T cell tolerance in Multiple Sclerosis autoimmunityR01AI121405 · NIAID · OHIO STATE UNIVERSITY · PI GUERAU-DE-ARELLANO, MIREIA · 2016 to 2020
$2.2M
Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung DiseaseR00HL131682 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BRITT, RODNEY · 2018 to 2020
$845k
Novel Epigenetic Modifier Inhibitor Drugs for T cell Modulation in Multiple SclerosisR21AI127354 · NIAID · OHIO STATE UNIVERSITY · PI GUERAU-DE-ARELLANO, MIREIA · 2017 to 2018
$404k
Novel knockout models to analyze CD38 functionR03AI151769 · NIAID · OHIO STATE UNIVERSITY · PI GUERAU-DE-ARELLANO, MIREIA · 2020 to 2021
$156k
NHLBI NIH HHS R00 HL131682NHLBI NIH HHS R01 HL155095NIAID NIH HHS R01 AI121405NIAID NIH HHS R03 AI151769NIAID NIH HHS R21 AI127354
6 · The paper itself

Abstract

While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.

Indexed as

AsthmaHydroxymethylglutaryl-CoA Reductase InhibitorsHumansSterolsHydroxymethylglutaryl-CoA Reductase InhibitorsSterolsasthmaneutrophilicseverestatinsterolTh17

Identifiers

PMID36041950
PMCPMC9513744
OpenAlexW4293879710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.