Evidence map›Paper›PMID 36041938›Full record

ArticleBiomaterials2022

A biomimetic multilayered polymeric material designed for heart valve repair and replacement.

Mingze Sun, Mohamed Elkhodiry, Lei Shi, Yingfei Xue, Maryam H Abyaneh, Alexander P Kossar, Caroline Giuglaris, Samuel L Carter, Richard L Li, Emile Bacha and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 44 citations in OpenAlex.

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  4. Materials Advances in Devices for Heart Disease Interventions.Advanced materials (Deerfield Beach, Fla.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mingze SunDepartment of Surgery, Columbia University, New York, NY, USA.
Mohamed ElkhodiryDepartment of Surgery, Columbia University, New York, NY, USA.
Lei ShiDepartment of Mechanical Engineering, Columbia University, New York, NY, USA.
Yingfei XueDepartment of Surgery, Columbia University, New York, NY, USA.
Maryam H AbyanehDepartment of Surgery, Columbia University, New York, NY, USA.
Alexander P KossarDepartment of Surgery, Columbia University, New York, NY, USA.
Caroline GiuglarisDepartment of Surgery, Columbia University, New York, NY, USA.
Samuel L CarterDepartment of Surgery, Columbia University, New York, NY, USA.
Richard L LiDepartment of Mechanical Engineering, Columbia University, New York, NY, USA.
Emile BachaDivision of Cardiac, Thoracic and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New-York Presbyterian - Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY, USA.
Giovanni FerrariDepartment of Surgery, Columbia University, New York, NY, USA.
Jeffrey KysarDepartment of Mechanical Engineering, Columbia University, New York, NY, USA.
Kristin MyersDepartment of Mechanical Engineering, Columbia University, New York, NY, USA.
David KalfaDepartment of Surgery, Columbia University, New York, NY, USA; Division of Cardiac, Thoracic and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New-York Presbyterian - Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: dk2757@cumc.columbia.edu.
Columbia University · USMorgan Stanley Children's Hospital · US

Funding

An expandable polymeric valved conduit to repair congenital heart diseaseR01HL155381 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FERRARI, GIOVANNI · 2021 to 2025
$2.8M
NHLBI NIH HHS R01 HL155381
6 · The paper itself

Abstract

Materials currently used to repair or replace a heart valve are not durable. Their limited durability related to structural degeneration or thrombus formation is attributed to their inadequate mechanical properties and biocompatibility profiles. Our hypothesis is that a biostable material that mimics the structure, mechanical and biological properties of native tissue will improve the durability of these leaflets substitutes and in fine improve the patient outcome. Here, we report the development, optimization, and testing of a biomimetic, multilayered material (BMM), designed to replicate the native valve leaflets. Polycarbonate urethane and polycaprolactone have been processed as film, foam, and aligned fibers to replicate the leaflet's architecture and anisotropy, through solution casting, lyophilization, and electrospinning. Compared to the commercialized materials, our BMMs exhibited an anisotropic behavior and a closer mechanical performance to the aortic leaflets. The material exhibited superior biostability in an accelerated oxidization environment. It also displayed better resistance to protein adsorption and calcification in vitro and in vivo. These results will pave the way for a new class of advanced synthetic material with long-term durability for surgical valve repair or replacement.

Indexed as

Biomimetic MaterialsHeart Valve ProsthesisAortic ValveBiomimeticsHeart ValvesHumansPolymersPolymersAnisotropyBiocompatibilityBiomimetic materialBiostabilityHeart valveMedical device development

Identifiers

PMID36041938
PMCPMC9801615
OpenAlexW4292837635

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.