ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Cortical Ripples during NREM Sleep and Waking in Humans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.Nature neuroscience · 2026Article
- Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
- GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.Translational psychiatry · 2026Article
- Global coincident bursts of high frequency oscillations across the human cortex coordinate large-scale memory processing.Nature communications · 2026Article
- Advances in Thalamic Neuromodulation for Epilepsy: From Mechanisms to Clinical Translation.Epilepsy currents · 2026Article
- Aperiodic 1/f noise drives ripple activity in humans.Nature communications · 2026Article
- Noradrenergic Slow Vasomotion: The Hidden Fluid Pump Linking Sleep, Brain Clearance, and Dementia Pathogenesis.International journal of molecular sciences · 2025Review
- Precise temporal dynamics of ripple events support order memory in human hippocampal-cortical circuits.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Episodic memory involves transient and sparse connectivity aligned to both internal and external events.PLoS biology · 2025Article
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.bioRxiv : the preprint server for biology · 2025Article
- Article
- Latent mechanisms of plasticity are upregulated during sleep.Current opinion in neurobiology · 2025Review
- Motifs of human high-frequency oscillations structure processing and memory of continuous audiovisual narratives.Science advances · 2025Article
- Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory.iScience · 2025Article
- Article
- Nitrogen waste metabolism as a locus of nitrergic co-transmission in the brain.Frontiers in behavioral neuroscience · 2025Review
- Multi-region processing during sleep for memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Hippocampal ripples index the reconstruction of spatiotemporal neuronal firing patterns essential for the consolidation of memories in the cortex during non-rapid eye movement sleep (NREM). Recently, cortical ripples in humans have been shown to enfold the replay of neuron firing patterns during cued recall. Here, using intracranial recordings from 18 patients (12 female), we show that cortical ripples also occur during NREM in humans, with similar density, oscillation frequency (∼90 Hz), duration, and amplitude to waking. Ripples occurred in all cortical regions with similar characteristics, unrelated to putative hippocampal connectivity, and were less dense and robust in higher association areas. Putative pyramidal and interneuron spiking phase-locked to cortical ripples during NREM, with phase delays consistent with ripple generation through pyramidal-interneuron feedback. Cortical ripples were smaller in amplitude than hippocampal ripples but were similar in density, frequency, and duration. Cortical ripples during NREM typically occurred just before the upstate peak, often during spindles. Upstates and spindles have previously been associated with memory consolidation, and we found that cortical ripples grouped cofiring between units within the window of spike timing-dependent plasticity. Thus, human NREM cortical ripples are as follows: ubiquitous and stereotyped with a tightly focused oscillation frequency; similar to hippocampal ripples; associated with upstates and spindles; and associated with unit cofiring. These properties are consistent with cortical ripples possibly contributing to memory consolidation and other functions during NREM in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.