Evidence map›Paper›PMID 36041828›Full record

ArticleeNeuro

Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex.

Brian A Upton, Gowri Nayak, Ivy Schweinzger, Shane P D'Souza, Charles V Vorhees, Michael T Williams, Brian R Earl, Richard A Lang

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. The physiological functions of OPN5m.Eye and vision (London, England) · 2025
    Review
  3. Article
  4. Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. A newbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Brian A UptonThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Gowri NayakThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Ivy SchweinzgerDepartment of Communication Sciences and Disorders, University of Cincinnati, College of Allied Health Sciences, Cincinnati, OH 45267.
Shane P D'SouzaThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Charles V VorheesDivision of Pediatric Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID https://orcid.org/0000-0003-3558-8812
Michael T WilliamsDivision of Pediatric Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID https://orcid.org/0000-0001-9841-9683
Brian R EarlDepartment of Communication Sciences and Disorders, University of Cincinnati, College of Allied Health Sciences, Cincinnati, OH 45267.
Richard A LangThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 richard.lang@cchmc.org.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
Regulation of vascular development in the eye by an opsin 5-dependent clockR01EY027077 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., RAO, SUJATA · 2016 to 2020
$2.4M
Regulation of eye development by an Opsin5-dopamine pathwayR01EY027711 · NEI · EMORY UNIVERSITY · PI IUVONE, P MICHAEL, LANG, RICHARD A. · 2017 to 2020
$1.9M
NEI NIH HHS R01 EY027077NEI NIH HHS R01 EY027711NIEHS NIH HHS P30 ES006096NIGMS NIH HHS T32 GM063483
6 · The paper itself

Abstract

Opsin-3 (

Indexed as

Reflex, StartleRod OpsinsAcoustic StimulationAnimalsMammalsMiceOpsinsOPN3 protein, mouseOpsinsRod Opsinsacoustic startleauditory brainstem responseencephalopsinlightopsinpanopsin

Identifiers

PMID36041828
PMCPMC9532019
OpenAlexW4293701215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.