Evidence map›Paper›PMID 36041656›Full record

ArticleThe Journal of allergy and clinical immunology2023

Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3.

Jonathan M Gaffin, Carter R Petty, Ronald L Sorkness, Loren C Denlinger, Brenda R Phillips, Ngoc P Ly, Benjamin Gaston, Kristie Ross, Anne Fitzpatrick, Leonard B Bacharier and 8 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
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  10. Article
  11. Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024
    Review
  12. Review
  13. Uncontrolled asthma in school-aged children-a nationwide specialist care study.The journal of allergy and clinical immunology. Global · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 1 country.

Jonathan M GaffinBoston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address: jonathan.gaffin@childrens.harvard.edu.
Carter R PettyBoston Children's Hospital, Harvard Medical School, Boston, Mass.
Ronald L SorknessUniversity of Wisconsin-Madison, Madison, Wis.
Loren C DenlingerUniversity of Wisconsin-Madison, Madison, Wis.
Brenda R PhillipsPennsylvania State University College of Medicine, Hershey, Pa.
Ngoc P LyUniversity of California San Francisco, San Francisco, Calif.
Benjamin GastonIndiana University School of Medicine, Indianapolis, Ind.
Kristie RossCase Western Reserve University, Cleveland, Ohio.
Anne FitzpatrickEmory University, Atlanta, Ga.
Leonard B BacharierVanderbilt University Medical Center, Nashville, Tenn.
Mark D DeBoerUniversity of Virginia, Charlottesville, Va.
W Gerald TeagueUniversity of Virginia, Charlottesville, Va.
Sally E WenzelUniversity of Pittsburgh, Pittsburgh, Pa.
Sima RamratnamUniversity of Wisconsin-Madison, Madison, Wis.
Elliot IsraelBrigham and Women's Hospital, Harvard Medical School, Boston, Mass.
David T MaugerPennsylvania State University College of Medicine, Hershey, Pa.
Wanda PhipatanakulBoston Children's Hospital, Harvard Medical School, Boston, Mass.
National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators
University of Wisconsin–Madison · USHarvard University · USPennsylvania State University · USUniversity of Virginia · USBoston Children's Hospital · USBrigham and Women's Hospital · USCase Western Reserve University · USEmory University · USIndiana University School of MedicineUniversity of California, San Francisco · USUniversity of Pittsburgh · USVanderbilt University Medical Center · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Rapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3M
Clinical Coordinating Center for the Severe Asthma Research Program (SARP)U10HL109086 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2011 to 2017
$8.1M
Wisconsin Allergy Research Training (WISCART) ProgramT32AI007635 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, DANIEL J JACKSON · 2000 to 2026
$6.5M
ALLERGENS IN INNER-CITY SCHOOLS AND CHILDHOOD ASTHMAR01AI073964 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2008 to 2012
$4.6M
AMSA: ALXR/FBR Mediated Signaling in Severe AsthmaU10HL109172 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, LEVY, BRUCE D · 2011 to 2016
$4.2M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Clinical and Molecular Phenotypes of Severe AsthmaU10HL109146 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2011 to 2016
$4.0M
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR002373NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109146NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10 HL109257NIAID NIH HHS R01 AI073964NIAID NIH HHS T32 AI007635NIEHS NIH HHS R01 ES030100
6 · The paper itself

Abstract

backgroundChildren with asthma are at risk for low lung function extending into adulthood, but understanding of clinical predictors is incomplete.

objectiveWe sought to determine phenotypic factors associated with FEV

methodsLung function was measured at baseline and annually. Multivariate linear mixed-effects models were constructed to assess the effect of baseline and time-varying predictors of prebronchodilator FEV

resultsA total of 862 spirometry assessments were performed for 188 participants. Factors associated with FEV

conclusionsIn children with severe and nonsevere asthma, several clinically relevant factors predict FEV

Indexed as

AsthmaAdultBronchodilator AgentsChildFemaleForced Expiratory VolumeHumansLungMaleRespiratory Function TestsSpirometryBronchodilator Agentsasthma exacerbationslung functionSevere asthmaspirometry

Identifiers

PMID36041656
PMCPMC9825637
OpenAlexW4293331337

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.