Evidence map›Paper›PMID 36041539›Full record

ArticleEnvironmental research2022

Interaction of maternal medication use with ambient heat exposure on congenital heart defects in the National Birth Defects Prevention Study.

Yanqiu Ou, Eleni A Papadopoulos, Sarah C Fisher, Marilyn L Browne, Ziqiang Lin, Aida Soim, Yi Lu, Scott Sheridan, Jennita Reefhuis, Peter H Langlois and 6 more

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In one paragraph

Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Yanqiu OuDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Eleni A PapadopoulosBirth Defects Registry, New York State Department of Health, Albany, NY, USA.
Sarah C FisherBirth Defects Registry, New York State Department of Health, Albany, NY, USA.
Marilyn L BrowneBirth Defects Registry, New York State Department of Health, Albany, NY, USA; Department of Epidemiology and Biostatistics, University at Albany, Rensselaer, NY, USA.
Ziqiang LinDepartment of Preventive Medicine, School of Basic Medicine and Public Health, Jinan University, Guangzhou, 510632, China.
Aida SoimBirth Defects Registry, New York State Department of Health, Albany, NY, USA.
Yi LuHealth Effects Institute, Boston, MA, USA.
Scott SheridanDepartment of Geography, Kent State University, Kent, OH, USA.
Jennita ReefhuisNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Peter H LangloisTexas Department of State Health Services, Austin, TX, USA; Department of Epidemiology, Human Genetics, and Environmental Science, UT Health School of Public Health, Austin, TX, USA.
Paul A RomittiDepartment of Epidemiology, The University of Iowa, Iowa City, IA, USA.
Erin M BellDepartment of Epidemiology and Biostatistics, University at Albany, Rensselaer, NY, USA; Department of Environmental Health Sciences, University at Albany, Rensselaer, NY, USA.
Marcia L FeldkampUniversity of Utah School of Medicine, Salt Lake City, UT, USA.
Sadia MalikUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA.
Shao LinDepartment of Epidemiology and Biostatistics, University at Albany, Rensselaer, NY, USA; Department of Environmental Health Sciences, University at Albany, Rensselaer, NY, USA. Electronic address: slin@albany.edu.
National Birth Defects Prevention Study

Funding

New York State Component A: BD-STEPS II CoreU01DD001227 · DD · CENTER OF ENVIRONMENTAL HEALTH · PI HOWLEY, MEREDITH M · 2018 to 2022
$4.2M
Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of PregnanR21ES021359 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI LIN, SHAO · 2012 to 2013
$321k
CDC HHSEPA EP-D-18-001HSRD VA CDP 13-003Intramural CDC HHS CC999999NCBDD CDC HHS U01 DD001227NCEH CDC HHS U38 EH000184NIEHS NIH HHS R21 ES021359
6 · The paper itself

Abstract

backgroundMaternal exposure to weather-related extreme heat events (EHEs) has been associated with congenital heart defects (CHDs) in offspring. Certain medications may affect an individual's physiologic responses to EHEs. We evaluated whether thermoregulation-related medications modified associations between maternal EHE exposure and CHDs.

methodsWe linked geocoded residence data from the U.S. National Birth Defects Prevention Study, a population-based case-control study, to summertime EHE exposures. An EHE was defined using the 90

resultsOver 45% of participants reported thermoregulation-related medication use during the critical period of cardiogenesis. Overall, these medications did not significantly modify the association between EHEs and CHDs. Still, medications that alter central thermoregulation increased aORs (95% CI) of EHE90 from 0.73 (0.41, 1.30) among non-users to 5.09 (1.20, 21.67) among users in the Southwest region, U.S. This effect modification was statistically significant on the multiplicative (P = 0.03) and additive scales, with an interaction contrast ratio (95% CI) of 1.64 (0.26, 3.02).

conclusionNo significant interaction was found for the maternal use of thermoregulation-related medications with EHEs on CHDs in general, while medications altering central thermoregulation significantly modified the association between EHEs and CHDs in Southwest U.S. This finding deserves further research.

Indexed as

Heart Defects, CongenitalHot TemperatureCase-Control StudiesFemaleHumansMaternal ExposureRisk FactorsExtreme heat eventsHeart defectsMedication use during pregnancyNBDPSThermoregulation

Identifiers

PMID36041539
PMCPMC10947356

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