ArticleAdvances in nutrition (Bethesda, Md.)2022
Perspective: Assessing Tolerance to Nondigestible Carbohydrate Consumption.
Article in Advances in nutrition (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Effects of Soluble Corn Fiber Consumption on Executive Functions and Gut Microbiota in Middle to Older Age Adults: A Randomized Controlled Crossover Trial.The Journal of nutrition · 2026Trial
- Short-chain oat fiber improves gastrointestinal tolerance and regulates glucose metabolism: a two-week open-label study in healthy adults.Frontiers in nutrition · 2026Trial
- Honey Added to Yogurt with Bifidobacterium animalis subsp. lactis DN-173 010/CNCM I-2494 Supports Probiotic Enrichment but Does Not Reduce Intestinal Transit Time in Healthy Adults: A Randomized, Controlled, Crossover Trial.The Journal of nutrition · 2024Trial
- A Diverse Fiber Mixture, Reflective of a Nutritionally Balanced Diet, Is Well Tolerated by Healthy Adults.Current developments in nutrition · 2026Article
- Article
- Safety of the extension of use of galacto-oligosaccharides as a novel food pursuant to Regulation (EU) 2015/2283.EFSA journal. European Food Safety Authority · 2025Article
- Association between daily calcium intake and the prevalence of chronic diarrhea: an analysis of NHANES 2005-2010 data.BMC gastroenterology · 2025Article
- Application of Functional Neurology Therapy in a Lactose-Intolerant Patient.Life (Basel, Switzerland) · 2024Article
- Dichotomous effect of dietary fiber in pediatrics: a narrative review of the health benefits and tolerance of fiber.European journal of clinical nutrition · 2024Review
- Dietary Patterns, Gut Microbiota and Sports Performance in Athletes: A Narrative Review.Nutrients · 2024Review
- Assessing Gastrointestinal Tolerance in Healthy Adults: Reliability and Validity of a Weekly Questionnaire.Current developments in nutrition · 2023Article
- Can prebiotics help tackle the childhood obesity epidemic?Frontiers in endocrinology · 2023Review
- Gastrointestinal Effects and Tolerance of Nondigestible Carbohydrate Consumption.Advances in nutrition (Bethesda, Md.) · 2022Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human intestinal enzymes do not hydrolyze nondigestible carbohydrates (NDCs), and thus, they are not digested and absorbed in the small intestine. Instead, NDCs are partially to completely fermented by the intestinal microbiota. Select NDCs are associated with health benefits such as laxation and lowering of blood cholesterol and glucose. NDCs provide functional attributes to processed foods, including sugar or fat replacers, thickening agents, and bulking agents. Additionally, NDCs are incorporated into processed foods to increase their fiber content. Although consumption of NDCs can benefit health and contribute functional characteristics to foods, they can cause gastrointestinal symptoms, such as flatulence and bloating. As gastrointestinal symptoms negatively affect consumer well-being and their acceptance of foods containing NDC ingredients, it is crucial to consider tolerance when designing food products and testing their physiological health benefits in clinical trials. This perspective provides recommendations for the approach to assess gastrointestinal tolerance to NDCs, with a focus on study design, population criteria, intervention, comparator, and outcome. Special issues related to studies in children and implications for stakeholders are also discussed. It is recommended that the evaluation of gastrointestinal tolerance to NDCs be conducted in randomized, blinded, controlled crossover studies using standard gastrointestinal questionnaires, with attention to study participant background diets, health status, lifestyle, and medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.