Evidence map›Paper›PMID 36040665›Full record

ArticleJournal of cancer research and clinical oncology2023

Longitudinal associations of sedentary behavior and physical activity with body composition in colorectal cancer survivors up to 2 years post treatment.

Marlou-Floor Kenkhuis, Mo Klingestijn, Anne-Marie Fanshawe, Stéphanie O Breukink, Maryska L G Janssen-Heijnen, Eric T P Keulen, Sabina Rinaldi, Paolo Vineis, Marc J Gunter, Michael F Leitzmann and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Association of patient factors and health-related quality of life with weight changes during chemotherapy for colorectal cancer: secondary analysis of the SCOT trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  2. Article
  3. Article
  4. Article
  5. Longitudinal associations of body composition with sleep problems in the first two years after colorectal cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 5 countries.

Marlou-Floor KenkhuisDepartment of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands. m.kenkhuis@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0002-4199-4326
Mo KlingestijnDepartment of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University as Part of an Internship, Maastricht University, Maastricht, The Netherlands.
Anne-Marie FanshaweDepartment of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University as Part of an Internship, Maastricht University, Maastricht, The Netherlands.
Stéphanie O BreukinkDepartment of Surgery, GROW School for Oncology and Reproduction, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Maryska L G Janssen-HeijnenDepartment of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.
Eric T P KeulenDepartment of Internal Medicine and Gastroenterology, Zuyderland Medical Centre, Sittard-Geleen, The Netherlands.
Sabina RinaldiNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France.
Paolo VineisMRC Centre for Environment and Health, School of Public Health, Imperial College, London, UK.
Marc J GunterNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France.
Michael F LeitzmannDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Augustin ScalbertNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France.
Matty P WeijenbergDepartment of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.
Martijn J L Bours *Department of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.
Eline H van Roekel *Department of Epidemiology, GROW School for Oncology and Reproduction, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.
Maastricht University · NLCentre international de recherche sur le cancer · FRItalian Institute of Technology · ITMaastricht University Medical Centre · NLUniversity of Regensburg · DEZuyderland Medisch Centrum · NL

Funding

Medical Research Council MR/S019669/1World Health Organization 001
6 · The paper itself

Abstract

purposeWe investigated longitudinal associations of sedentary behavior, light-intensity physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) with body composition in colorectal cancer (CRC) survivors, between 6 weeks and 24 months post treatment. In addition, we explored whether body composition mediated associations of sedentary behavior and MVPA with fatigue.

methodsA prospective cohort study was conducted in 459 stage I-III CRC patients recruited at diagnosis. Measurements were performed of accelerometer-assessed sedentary time (hours/day), self-reported LPA and MVPA (hours/week), anthropometric assessment of body mass index (BMI), waist circumference and fat percentage (measures of adiposity), and muscle circumference and handgrip strength (measures of muscle mass/function) repeated at 6 weeks, and 6, 12 and 24 months post treatment. Longitudinal associations of sedentary time and physical activity with body composition were analyzed using confounder-adjusted linear mixed models. Mediation analyses were performed to explore the role of body mass index (BMI) and handgrip strength as mediators in associations of sedentary time and MVPA with fatigue.

resultsLess sedentary time and LPA were, independent of MVPA, longitudinally associated with increased handgrip strength, but not with measures of adiposity. More MVPA was associated with increased adiposity and increased handgrip strength. Higher BMI partly mediated associations between higher sedentary time and more fatigue.

conclusionWithin the first two years after CRC treatment, changes in sedentary behavior, physical activity and body composition are interrelated and associated with fatigue. Intervention studies are warranted to investigate causality.

trial registrationThe EnCoRe study is registered at trialregister.nl as NL6904 (former ID: NTR7099).

Indexed as

Cancer SurvivorsColorectal NeoplasmsBody CompositionBody Mass IndexExerciseFatigueHand StrengthHumansObesityProspective StudiesSedentary BehaviorBody compositionColorectal cancer survivorsFatiguePhysical activitySedentary behavior

Identifiers

PMID36040665
PMCPMC10314855
OpenAlexW4293770414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.