Evidence map›Paper›PMID 36040598›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Stent-Based Gene Delivery for Coronary Disease.

Ivan S Alferiev, Michael Chorny, Robert L Wilensky, Robert J Levy, Ilia Fishbein

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ivan S AlferievThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Michael ChornyThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Robert L WilenskyThe University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Robert J LevyThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ilia FishbeinThe Children's Hospital of Philadelphia, Philadelphia, PA, USA. fishbein@chop.edu.
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

Oxidation Resistant ApoA1 Gene Delivery StentsR01HL137762 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI FISHBEIN, ILIA, LEVY, ROBERT J · 2017 to 2020
$3.3M
NHLBI NIH HHS R01 HL137762
6 · The paper itself

Abstract

Percutaneous coronary interventions (PCI) are the mainstay for treatment of advanced coronary disease. A majority of PCI involve deployment of a stent in the affected vascular segment. This chapter introduces the concept of using stents as a platform for delivering gene therapies to the vasculature with the overarching aim of mitigating in-stent restenosis (ISR), late stent thrombosis (LST), and neoatherosclerosis (NA), a triad of delayed complications that reduce the overall success rate of PCI. The chapter provides a detailed methodology for coatless reversible attachment of adenoviral (Ad) and adeno-associated viral (AAV) vectors to the metal stent struts along with representative in vitro and in vivo results.

Indexed as

Coronary Artery DiseaseCoronary RestenosisPercutaneous Coronary InterventionGene Transfer TechniquesHumansStentsTreatment OutcomeAdeno-associated virusAdenovirusFluorescent microscopyGene therapyGreen fluorescent proteinIn-stent restenosisLuciferaseStentsSubstrate-mediated gene transfer

Identifiers

PMID36040598
PMCPMC10444541
OpenAlexW4293568620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.