Evidence map›Paper›PMID 36040521›Full record

ArticleActa neuropathologica2022

Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging.

Abris Gilvesy, Evelina Husen, Zsofia Magloczky, Orsolya Mihaly, Tibor Hortobágyi, Shigeaki Kanatani, Helmut Heinsen, Nicolas Renier, Tomas Hökfelt, Jan Mulder and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 63 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Vulnerability of locus coeruleus connections to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  12. Article
  13. Article
  14. Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 9 countries.

Abris GilvesyDepartment of Neuroscience, Karolinska Institutet, Solnavägen 9, 17177, Stockholm, Sweden.
Evelina HusenDepartment of Neuroscience, Karolinska Institutet, Solnavägen 9, 17177, Stockholm, Sweden.
Zsofia MagloczkyHuman Brain Research Laboratory, Institute of Experimental Medicine, ELKH, Budapest, Hungary.
Orsolya MihalyDepartment of Pathology, St. Borbála Hospital, Tatabánya, Hungary.
Tibor HortobágyiDepartment of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Shigeaki KanataniDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177, Stockholm, Sweden.
Helmut HeinsenClinic of Psychiatry and Institute of Forensic Pathology, University of Würzburg, 97080, Würzburg, Germany.
Nicolas RenierSorbonne Université, Paris Brain Institute-ICM, INSERM, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, 75013, Paris, France.
Tomas HökfeltDepartment of Neuroscience, Karolinska Institutet, Solnavägen 9, 17177, Stockholm, Sweden.
Jan MulderDepartment of Neuroscience, Karolinska Institutet, Solnavägen 9, 17177, Stockholm, Sweden.
Mathias UhlenDepartment of Neuroscience, Karolinska Institutet, Solnavägen 9, 17177, Stockholm, Sweden.
Gabor G KovacsTanz Centre for Research in Neurodegenerative Disease and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Csaba AdoriDepartment of Neuroscience, Karolinska Institutet, Solnavägen 9, 17177, Stockholm, Sweden. csaba.adori@ki.se.ORCID http://orcid.org/0000-0002-6084-5588
Karolinska Institutet · SECentre National de la Recherche Scientifique · FRHUN-REN Institute of Experimental Medicine · HUScience for Life Laboratory · SESzent Borbála Kórház · HUUniversidade de São Paulo · BRUniversity Health Network · CAUniversity of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tau pathology of the noradrenergic locus coeruleus (LC) is a hallmark of several age-related neurodegenerative disorders, including Alzheimer's disease. However, a comprehensive neuropathological examination of the LC is difficult due to its small size and rod-like shape. To investigate the LC cytoarchitecture and tau cytoskeletal pathology in relation to possible propagation patterns of disease-associated tau in an unprecedented large-scale three-dimensional view, we utilized volume immunostaining and optical clearing technology combined with light sheet fluorescence microscopy. We examined AT8

Indexed as

Alzheimer DiseaseLocus CoeruleusHumansImaging, Three-DimensionalNeurofibrillary Tanglestau Proteinstau ProteinsAlzheimer’s diseaseLocus coeruleusTau pathologyThree-dimensional, iDISCO, light sheet fluorescence microscopy

Identifiers

PMID36040521
PMCPMC9468059
OpenAlexW4293591925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.