Evidence map›Paper›PMID 36040206›Full record

ArticleJournal of clinical microbiology2022

Specific and Sensitive Diagnosis of Babesia microti Active Infection Using Monoclonal Antibodies to the Immunodominant Antigen BmGPI12.

Jacqueline Gagnon, Sushma Timalsina, Jae-Yeon Choi, Meenal Chand, Pallavi Singh, Pooja Lamba, Gauri Gaur, Anasuya C Pal, Sara Mootien, Luis A Marcos and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Human babesiosis: The past, present and future.Expert reviews in molecular medicine · 2025
    Review
  3. Article
  4. Research progress on diagnostic techniques for differentFrontiers in cellular and infection microbiology · 2025
    Review
  5. A set of diagnostic tests for detection of active Babesia duncani infection.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  6. Identification ofInfection and immunity · 2024
    Article
  7. Transfusion-transmittedJournal of clinical microbiology · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jacqueline GagnonL2 Diagnostics, LLC, New Haven, Connecticut, USA.
Sushma TimalsinaL2 Diagnostics, LLC, New Haven, Connecticut, USA.
Jae-Yeon ChoiDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Meenal ChandDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Pallavi SinghDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Pooja LambaDepartment of Medicine (Division of Infectious Diseases), Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Gauri GaurL2 Diagnostics, LLC, New Haven, Connecticut, USA.
Anasuya C PalDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Sara MootienL2 Diagnostics, LLC, New Haven, Connecticut, USA.
Luis A MarcosDepartment of Medicine (Division of Infectious Diseases), Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Choukri Ben MamounDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.ORCID 0000-0001-5028-1400
Michel LedizetL2 Diagnostics, LLC, New Haven, Connecticut, USA.ORCID 0000-0002-0873-2906
Yale University · USStony Brook School · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Fosinopril analogs for the treatment of human babesiosisR01AI153100 · NIAID · YALE UNIVERSITY · PI BEN MAMOUN, CHOUKRI · 2021 to 2025
$3.6M
Hit-to-Lead Development of the Kalihinol Scaffold for Malaria TreatmentR01AI138139 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEN MAMOUN, CHOUKRI, LE ROCH, KARINE GAELLE · 2018 to 2022
$3.6M
Development of endochin-like quinolones for babesiosis therapyR01AI123321 · NIAID · YALE UNIVERSITY · PI BEN MAMOUN, CHOUKRI · 2017 to 2020
$2.7M
Antigen Discovery and Vaccine Development for Human Babesia ParasitesR01AI152220 · NIAID · YALE UNIVERSITY · PI BEN MAMOUN, CHOUKRI · 2020 to 2024
$2.1M
An antigen-detection assay to diagnose Babesia microti infectionR44AI136118 · NIAID · L2 DIAGNOSTICS, LLC · PI LEDIZET, MICHEL · 2020 to 2022
$2.1M
An antigen-detection assay to diagnose Babesia microti infectionR43AI136118 · NIAID · L2 DIAGNOSTICS, LLC · PI LEDIZET, MICHEL · 2018 to 2018
$300k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI123321NIAID NIH HHS R01 AI138139NIAID NIH HHS R01 AI152220NIAID NIH HHS R01 AI153100NIAID NIH HHS R43 AI136118NIAID NIH HHS R44 AI136118NIH HHS 5R44AI136118Steven and Alexandra Cohen Foundation (Steven & Alexandra Cohen Foundation) Lyme 62 2020
6 · The paper itself

Abstract

The apicomplexan pathogen Babesia microti is responsible for most cases of human babesiosis worldwide. The disease, which presents as a malaria-like illness, is potentially fatal in immunocompromised or elderly patients, making the need for its accurate and early diagnosis an urgent public health concern. B. microti is transmitted primarily by

Indexed as

Babesia microtiBabesiosisAgedAntibodies, MonoclonalAntigens, ProtozoanHumansRNAAntibodies, MonoclonalAntigens, ProtozoanRNAantigen capture assayBabesiadiagnosismonoclonal antibodies

Identifiers

PMID36040206
PMCPMC9491189
OpenAlexW4293567490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.