Evidence map›Paper›PMID 36040164›Full record

ArticleMicrobiology spectrum2022

Novel Requirement for Staphylococcal Cell Wall-Anchored Protein SasD in Pulmonary Infection.

Jennifer A Grousd, Brooke P Dresden, Abigail M Riesmeyer, Vaughn S Cooper, Jennifer M Bomberger, Anthony R Richardson, John F Alcorn

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jennifer A GrousdDepartment of Immunology, University of Pittsburghgrid.21925.3dgrid.471408.egrid.21925.3d, Pittsburgh, Pennsylvania, USA.
Brooke P DresdenDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Abigail M RiesmeyerDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Vaughn S CooperDepartment of Microbiology & Molecular Genetics, University of Pittsburghgrid.21925.3dgrid.471408.egrid.21925.3d, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7726-0765
Jennifer M BombergerDepartment of Microbiology & Molecular Genetics, University of Pittsburghgrid.21925.3dgrid.471408.egrid.21925.3d, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-4767-6238
Anthony R RichardsonDepartment of Microbiology & Molecular Genetics, University of Pittsburghgrid.21925.3dgrid.471408.egrid.21925.3d, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1123-0242
John F AlcornDepartment of Immunology, University of Pittsburghgrid.21925.3dgrid.471408.egrid.21925.3d, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USChildren's Hospital of Pittsburgh · US

Funding

Influenza A Inhibits TH17 Host Defense Against Bacterial PneumoniaR01HL107380 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALCORN, JOHN F · 2012 to 2024
$5.4M
Immunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3M
Polymicrobial Interactions in the Respiratory TractR01HL142587 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOMBERGER, JENNIFER MELINDA · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL107380NHLBI NIH HHS R01 HL142587NIAID NIH HHS T32 AI060525
6 · The paper itself

Abstract

Staphylococcus aureus can complicate preceding viral infections, including influenza virus. A bacterial infection combined with a preceding viral infection, known as superinfection, leads to worse outcomes than a single infection. Most of the pulmonary infection literature focuses on the changes in immune responses to bacteria between homeostatic and virally infected lungs. However, it is unclear how much of an influence bacterial virulence factors have in single or superinfection. Staphylococcal species express a broad range of cell wall-anchored proteins (CWAs) that have roles in host adhesion, nutrient acquisition, and immune evasion. We screened the importance of these CWAs using mutants lacking individual CWAs

Indexed as

Influenza, HumanPneumonia, BacterialPneumonia, StaphylococcalStaphylococcal InfectionsSuperinfectionAnimalsCell WallHumansInterleukin-1betaLungMembrane ProteinsMiceMice, KnockoutStaphylococcus aureusVirulence FactorsInterleukin-1betaMembrane ProteinsVirulence FactorsinfluenzalungmacrophagesMRSApneumonia

Identifiers

PMID36040164
PMCPMC9603976
OpenAlexW4293567416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.