Evidence map›Paper›PMID 36039656›Full record

ReviewEuropean journal of heart failure2022

Congestion in heart failure: a circulating biomarker-based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology.

Julio Núñez, Rafael de la Espriella, Patrick Rossignol, Adriaan A Voors, Wilfried Mullens, Marco Metra, Ovidiu Chioncel, James L Januzzi, Christian Mueller, A Mark Richards and 33 more

Erratum issuedAbstract readReview
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In one paragraph

Review in European journal of heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  7. Characterizing the molecular landscape of venous congestion.World journal of critical care medicine · 2026
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors.

Julio NúñezHospital Clínico Universitario de Valencia, INCLIVA, Universidad de Valencia, Valencia, Spain.
Rafael de la EspriellaHospital Clínico Universitario de Valencia, INCLIVA, Universidad de Valencia, Valencia, Spain.
Patrick RossignolUniversité de Lorraine, INSERM, Centre d'Investigations Cliniques-Plurithématique 14-33, INSERM U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
Adriaan A VoorsDepartment of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Wilfried MullensHospital Oost-Limburg, Genk, Belgium.
Marco MetraDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, Cardiology. ASST Spedali Civili, University of Brescia, Brescia, Italy.
Ovidiu ChioncelEmergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu', University of Medicine Carol Davila, Bucharest, Romania.
James L JanuzziMassachusetts General Hospital and Baim Institute for Clinical Research, Boston, MA, USA.
Christian MuellerDepartment of Cardiology, University Hospital, Basel, Switzerland.
A Mark RichardsCardiovascular Research Institute, National University of Singapore, Singapore, Singapore.
Rudolf A de BoerDepartment of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Thomas ThumInstitute of Molecular and Translational Therapeutic Strategies (IMTTS) and Rebirth Center for Translational Regenerative Therapies, Hannover Medical School, Hannover, Germany.
Henrike ArfstenClinical Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Arantxa GonzálezCIBER Cardiovascular, Madrid, Spain.
Magdy AbdelhamidFaculty of Medicine, Cairo University, Giza, Egypt.
Stamatis Adamopoulos2nd Department of Cardiovascular Medicine, Onassis Cardiac Surgery Center, Athens, Greece.
Stefan D AnkerDepartment of Cardiology (CVK); and Berlin Institute of Health Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany.
Tuvia Ben GalCardiology Department, Rabin Medical Center, Petah Tikva, Israel.
Jan BiegusInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Alain Cohen-SolalInserm 942 MASCOT, Université de Paris, AP-HP, Hopital Lariboisière, Paris, France.
Michael BöhmUniversitätsklinikum des Saarlandes, Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin Homburg/Saar, Saarland University, Saarbrücken, Germany.
Michele EmdinInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Ewa A JankowskaInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Finn GustafssonRigshospitalet-Copenhagen University Hospital, Heart Centre, Department of Cardiology, Copenhagen, Denmark.
Loreena HillQueen's University Belfast, Belfast, UK.
Tiny JaarsmaLinkoping University, Linkoping, Sweden.
Pardeep S JhundBHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Yuri LopatinVolgograd State Medical University, Volgograd, Russia.
Lars H LundDepartment of Medicine, Karolinska Institutet, and Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden.
Davor MilicicUniversity of Zagreb, School of Medicine, Zagreb, Croatia.
Brenda MouraFaculty of Medicine, University of Porto, Porto, Portugal.
Massimo F PiepoliCardiology Division, Castel San Giovanni Hospital, Castel San Giovanni, Italy.
Piotr PonikowskiInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Amina RakishevaScientific Research Institute of Cardiology and Internal Medicine, Almaty, Kazakhstan.
Arsen RisticSchool of Medicine, University of Belgrade, Belgrade, Serbia.
Gianluigi SavareseDepartment of Medicine, Karolinska Institutet, and Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden.
Carlo G TocchettiCardio-Oncology Unit, Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy.
Sophie Van LinthoutGerman Centre for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany.
Maurizio VolterraniIRCCS San Raffaele, Rome, Italy.
Petar SeferovicFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Giuseppe RosanoSt. George's Hospitals NHS Trust University of London, London, UK.
Andrew J S CoatsUniversity of Warwick, Coventry, UK.
Antoni Bayes-GenisCIBER Cardiovascular, Madrid, Spain.ORCID 0000-0002-3044-197X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congestion is a cardinal sign of heart failure (HF). In the past, it was seen as a homogeneous epiphenomenon that identified patients with advanced HF. However, current evidence shows that congestion in HF varies in quantity and distribution. This updated view advocates for a congestive-driven classification of HF according to onset (acute vs. chronic), regional distribution (systemic vs. pulmonary), compartment of distribution (intravascular vs. extravascular), and clinical vs. subclinical. Thus, this review will focus on the utility of circulating biomarkers for assessing and managing the different fluid overload phenotypes. This discussion focused on the clinical utility of the natriuretic peptides, carbohydrate antigen 125 (also called mucin 16), bio-adrenomedullin and mid-regional pro-adrenomedullin, ST2 (also known as interleukin-1 receptor-like 1), cluster of differentiation 146, troponin, C-terminal pro-endothelin-1, and parameters of haemoconcentration. The utility of circulation biomarkers on top of clinical evaluation, haemodynamics, and imaging needs to be better determined by dedicated studies. Some multiparametric frameworks in which these tools contribute to management are proposed.

Indexed as

CardiologyHeart FailureAdrenomedullinBiomarkersHumansPrognosisAdrenomedullinBiomarkersAcute heart failureBiomarkersCongestion

Identifiers

PMID36039656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.