Evidence map›Paper›PMID 36039649›Full record

ArticleImmunity, inflammation and disease2022

SAMD1 attenuates antiphospholipid syndrome-induced vascular injury and pregnancy complications.

Ran An, Yanqi Yang, Lei Liu, Peiling Li

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ran AnDepartment of Obstetrics and Gynecology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yanqi YangDepartment of Obstetrics and Gynecology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Lei LiuDepartment of Obstetrics and Gynecology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Peiling LiDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.ORCID 0000-0003-1006-3825
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was intended to investigate the effect of SAMD1 on antiphospholipid syndrome (APS)-induced vascular injury in human umbilical vein endothelial cells (HUVECs) and pregnancy complications in mice.

methodsThe expression of SAMD1 in APS patients and healthy controls was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Anti-B

resultsSAMD1 expression was low in serum of APS patients, which was correlated with the history of thrombosis and the number of adverse pregnancies. Anti-B

conclusionSAMD1 may reduce APS-induced vascular injury and embryo loss by regulating cellular senescence, proliferation, migration, and angiogenesis.

Indexed as

Antiphospholipid SyndromePregnancy ComplicationsVascular System InjuriesAnimalsFemaleHumansHuman Umbilical Vein Endothelial CellsIntercellular Adhesion Molecule-1Matrix Metalloproteinase 9MicePregnancyReceptors, LDLIntercellular Adhesion Molecule-1Matrix Metalloproteinase 9Receptors, LDLSAMD1 protein, humanantiphospholipid syndromeembryo lossSAMD1vascular injury

Identifiers

PMID36039649
PMCPMC9382866
OpenAlexW4292092643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.