Evidence map›Paper›PMID 36039308›Full record

ArticleInternational journal of general medicine2022

Establishment of Reference Intervals for Serum Protein Electrophoresis of Apparently Healthy Adults in Addis Ababa, Ethiopia.

Demiraw Bikila, Tadesse Lejisa, Yosef Tolcha, Chala Bashea, Mehari Meles, Tigist Getahun, Genet Ashebir, Wossene Habtu, Feyissa Challa, Ousman Mohammed and 6 more

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Article in International journal of general medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Demiraw BikilaDepartment of National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-3906-5018
Tadesse LejisaDepartment of National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0003-0382-5000
Yosef TolchaDepartment of National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-0783-8127
Chala BasheaDepartment of National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-5804-2153
Mehari MelesDepartment of National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Tigist GetahunDepartment of National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0001-6899-7247
Genet AshebirDepartment of National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Wossene HabtuDepartment of National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-1580-7195
Feyissa ChallaDepartment of National Clinical Chemistry Reference Laboratory, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-2624-6661
Ousman MohammedDepartment of Medical Laboratory Sciences, Wollo University, Dessie, Ethiopia.ORCID 0000-0002-6855-2827
Melkitu KassawFood Science and Nutrition Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-0428-4915
Adisu KebedeNational Capacity Building Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Letebrhan G/EgzeabherDepartment of Medical Laboratory, Yekatit 12 General Hospital, Addis Ababa, Ethiopia.
Endalkachew BefekaduDepartment of Medical Laboratory, Saint Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.
Mistire WoldeDepartment of Medical Laboratory Sciences, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.ORCID 0000-0002-1245-403X
Aster TsegayeDepartment of Medical Laboratory Sciences, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.ORCID 0000-0002-9026-4629

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Even though several factors affect reference intervals (RIs), company-derived values are currently in use in many laboratories worldwide. However, few or no data are available regarding serum proteins RIs, especially in resource-limited countries such as Ethiopia. Objective: To establish RIs for serum protein electrophoresis of apparently healthy adults in Addis Ababa, Ethiopia. Methods: A cross-sectional study was conducted on a total of 297 apparently healthy adults from April to October 2019 in four selected sub-cities (Akaki, Kirkos, Arada, and Yeka) of Addis Ababa, Ethiopia. Laboratory analysis of collected samples was performed using the Capillarys 2 Flex Piercing analyzer, while statistical analysis was conducted using SPSS version 23 and Med-Calc software. The Mann-Whitney test was used to check partitions. A non-parametric method of reference range establishment was performed as per CLSI guideline EP28A3C. Results: The established RIs were: albumin 53.83-64.59%, 52.24-63.55%; alpha-1 globulin 3.04-5.40%, 3.44-5.60%; alpha-2 globulin 8.0-12.67%, 8.44-12.87%; and beta-1 globulin 5.01-7.38%, 5.14-7.86%. Moreover, the albumin to globulin ratios were 1.16-1.8 and 1.09-1.74 for males and females, respectively. The combined RIs for beta-2 globulin and gamma globulin were 2.54-4.90% and 12.40-21.66%, respectively. Conclusion: The established reference interval for serum protein fractions revealed gender-specific differences, except for beta-2 globulin and gamma globulin.

Indexed as

Addis AbabaEthiopiareference intervalserum protein electrophoresis

Identifiers

PMID36039308
PMCPMC9419900

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