Evidence map›Paper›PMID 36039299›Full record

ArticleiScience2022

Integrative analysis of spatial transcriptome with single-cell transcriptome and single-cell epigenome in mouse lungs after immunization.

Zhongli Xu, Xinjun Wang, Li Fan, Fujing Wang, Becky Lin, Jiebiao Wang, Giraldina Trevejo-Nuñez, Wei Chen, Kong Chen

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Zhongli XuDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Xinjun WangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
Li FanDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Fujing WangDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Becky LinDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jiebiao WangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
Giraldina Trevejo-NuñezDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Wei ChenDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Kong ChenDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · US

Funding

Project 2 Impact of Innate and Adaptive Immunity At the Airway Epithelium in Severe AsthmaP01AI106684 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Anuradha Ray · 2015 to 2026
$18.9M
Epigenetic regulation of chemokines in lung inflammationR01HL137709 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2018 to 2021
$1.6M
Epigenetic regulation of chemokines in lung inflammationR56HL137709 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2017 to 2017
$387k
NHLBI NIH HHS R01 HL137709NHLBI NIH HHS R56 HL137709NIAID NIH HHS P01 AI106684
6 · The paper itself

Abstract

Understanding lung immunity requires an unbiased profiling of tissue-resident T cells at their precise anatomical locations within the lung, but such information has not been characterized in the immunized mouse model. In this pilot study, using 10x Genomics Chromium and Visium platform, we performed an integrative analysis of spatial transcriptome with single-cell RNA-seq and single-cell ATAC-seq on lung cells from mice after immunization using a well-established

Indexed as

Biological sciencesImmunologyOmicsTranscriptomics

Identifiers

PMID36039299
PMCPMC9418911
OpenAlexW4290795096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.