Evidence map›Paper›PMID 36039261›Full record

ReviewCureus2022

Drug-Induced Hyperthermia Review.

Michael Horseman, Ladan Panahi, George Udeani, Andrew S Tenpas, Rene Verduzco, Pooja H Patel, Daniela Z Bazan, Andrea Mora, Nephy Samuel, Anne-Cecile Mingle and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michael HorsemanPharmacy Practice, Texas A&M University, Kingsville, USA.
Ladan PanahiPharmacy Practice, Texas A&M University, Kingsville, USA.
George UdeaniPharmacy Practice, Texas A&M University, Kingsville, USA.
Andrew S TenpasPharmacy Practice, Texas A&M University, Kingsville, USA.
Rene VerduzcoPharmacy Practice, Texas A&M University, Kingsville, USA.
Pooja H PatelPharmacy Practice, Texas A&M University, Kingsville, USA.
Daniela Z BazanPharmacy Practice, Texas A&M University, Kingsville, USA.
Andrea MoraPharmacy Practice, Texas A&M University, Kingsville, USA.
Nephy SamuelPharmacy Practice, Texas A&M University, Kingsville, USA.
Anne-Cecile MinglePharmacy Practice, Texas A&M University, Kingsville, USA.
Lisa R LeonThermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, USA.
Joseph VaronCritical Care, United General Hospital, Houston, USA.
Salim SuraniMedicine, Texas A&M University, College Station, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans maintain core body temperature via a complicated system of physiologic mechanisms that counteract heat/cold fluctuations from metabolism, exertion, and the environment. Overextension of these mechanisms or disruption of body temperature homeostasis leads to bodily dysfunction, culminating in a syndrome analogous to exertional heat stroke (EHS). The inability of this thermoregulatory process to maintain the body temperature is caused by either thermal stress or certain drugs. EHS is a syndrome characterized by hyperthermia and the activation of systemic inflammation. Several drug-induced hyperthermic syndromes may resemble EHS and share common mechanisms. The purpose of this article is to review the current literature and compare exertional heat stroke (EHS) to three of the most widely studied drug-induced hyperthermic syndromes: malignant hyperthermia (MH), neuroleptic malignant syndrome (NMS), and serotonin syndrome (SS). Drugs and drug classes that have been implicated in these conditions include amphetamines, diuretics, cocaine, antipsychotics, metoclopramide, selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and many more. Observations suggest that severe or fulminant cases of drug-induced hyperthermia may evolve into an inflammatory syndrome best described as heat stroke. Their underlying mechanisms, symptoms, and treatment approaches will be reviewed to assist in accurate diagnosis, which will impact the management of potentially life-threatening complications.

Indexed as

drug-induced hyperthermiaheat strokehyperthermiamalignant hyperthermia (mh)neuroleptic malignant syndrome (nms)serotonin syndrome (ss)thermoprotection

Identifiers

PMID36039261
PMCPMC9403255

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.