Evidence map›Paper›PMID 36039055›Full record

ArticleOncology letters2022

Immunoexpression of p62/SQSTM1/Sequestosome-1 in human primary and recurrent IDH1/2 wild-type glioblastoma: A pilot study.

Antonio Ieni, Cristina Pizzimenti, Giuseppe Broggi, Rosario Caltabiano, Antonino Germanò, Giuseppe Maria Vincenzo Barbagallo, Paolo Vigneri, Giuseppe Giuffrè, Giovanni Tuccari

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. The multiple roles of autophagy in uveal melanoma and the microenvironment.Journal of cancer research and clinical oncology · 2024
    Pooled it
  2. Review
  3. Formyl Peptide Receptor-2-Suppressed Autophagy Promotes the Migration and Invasion of Human Glioblastoma Cells Through PI3K/Akt Signaling.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Antonio IeniDepartment of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Section of Pathology, University of Messina, I-98125 Messina, Italy.
Cristina PizzimentiDepartment of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, I-98125 Messina, Italy.
Giuseppe BroggiDepartment of Medical, Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', Section of Anatomic Pathology, University of Catania, I-95123 Catania, Italy.
Rosario CaltabianoDepartment of Medical, Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', Section of Anatomic Pathology, University of Catania, I-95123 Catania, Italy.
Antonino GermanòDepartment of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, I-98125 Messina, Italy.
Giuseppe Maria Vincenzo BarbagalloDepartment of Medical, Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', Section of Neurological Surgery, Policlinico 'Rodolico-San Marco' University Hospital, University of Catania, I-95123 Catania, Italy.
Paolo VigneriDepartment of Clinical and Experimental Medicine, University of Catania, I-95123 Catania, Italy.
Giuseppe GiuffrèDepartment of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Section of Pathology, University of Messina, I-98125 Messina, Italy.
Giovanni TuccariDepartment of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Section of Pathology, University of Messina, I-98125 Messina, Italy.
University of Catania · ITUniversity of Messina · ITIstituto Ortopedico Gaetano Pini · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

p62/SQSTM1/Sequestosome-1 is an autophagic protein that serves a crucial role in cellular metabolism, proliferation and malignant growth. Notably, autophagy may influence the development and resistance to therapy of numerous types of human cancer. In the present pilot study, the immunohistochemical pattern of p62 was analyzed in a cohort of patients with isocitrate dehydrogenase (IDH)1/2 wild-type glioblastoma (GBM), in primary and recurrent samples, in order to verify the concordance or discordance between the primary and recurrent tumors. In addition, the association between p62, and patient outcome and O

Indexed as

autophagyglioblastomaimmuno-histochemistryO6-methylguanine-DNA methyltransferasep62/SQSTM1/Sequestosome-1

Identifiers

PMID36039055
PMCPMC9404704
OpenAlexW4290995852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.