ArticleUltrasonography (Seoul, Korea)2022
Malignancy risk of thyroid nodules with minimal cystic changes: a multicenter retrospective study.
Article in Ultrasonography (Seoul, Korea), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Malignant Risk Assessment of Cystic-solid Thyroid Nodules Based on Multimodal Ultrasound Features: A Systematic Review and Meta-analysis.Current medical imaging · 2025Pooled it
- 2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management.European thyroid journal · 2023Guideline
- Radiofrequency ablation for symptomatic, non-functioning thyroid nodules: a single-center retrospective observational study.Annals of surgical treatment and research · 2025Article
- Article
- Machine learning-based quantification of overall and internal ultrasound characteristics for diagnosing malignant partially cystic thyroid nodules.Frontiers in endocrinology · 2025Article
- Bilateral papillary thyroid cancer: pitfalls of ACR TI-RADS and evaluation of modified parameters.Endocrine · 2024Article
- Comparative analysis of machine learning-based ultrasound radiomics in predicting malignancy of partially cystic thyroid nodules.Endocrine · 2024Article
- [Clinical Application of the 2021 Korean Thyroid Imaging Reporting and Data System (K-TIRADS)].Journal of the Korean Society of Radiology · 2023Review
- Follow-up of benign thyroid nodules confirmed by ultrasound-guided core needle biopsy after inconclusive cytology on fine-needle aspiration biopsy.Ultrasonography (Seoul, Korea) · 2023Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this multicenter study was to investigate the malignancy risk of minimally cystic thyroid nodules (MCTNs) using cyto-histopathologic diagnoses as the reference standard.
methodsFrom June 2015 to September 2015, 5,601 thyroid nodules (≥1 cm) from 4,989 consecutive patients who underwent thyroid ultrasonography (US) at 26 institutions were retrospectively analyzed. Each thyroid nodule was categorized according to its cystic proportion: purely solid, minimally cystic (≤10%), and partially cystic (>10%). The malignancy risk of MCTNs was compared with those of purely solid nodules and partially cystic thyroid nodules (PCTNs). The malignancy risk of MCTNs was assessed according to echogenicity and the presence of suspicious US features.
resultsThe prevalence of MCTNs was 22.5%. The overall malignancy risk of MCTNs was 8.8%, which was significantly lower than that of purely solid nodules (29.5%) (P<0.001), and slightly higher than that of PCTNs (6.2%) (P=0.013). The risk of malignancy associated with MCTNs was similar to that of PCTNs regardless of echogenicity or the presence of suspicious US features (all P>0.05). MCTNs were associated with a higher risk of malignancy in hypoechoic nodules than in isohyperechoic nodules and in nodules with suspicious US features than in those without suspicious US features (all P<0.001).
conclusionThe malignancy risk of MCTNs was significantly lower than that of purely solid nodules. MCTNs could be categorized as PCTNs rather than as solid nodules to increase the accuracy of the risk stratification system for thyroid nodules.
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