Evidence map›Paper›PMID 36038921›Full record

ArticleMalaria journal2022

Haematological profile of malaria patients with G6PD and PKLR variants (erythrocytic enzymopathies): a cross-sectional study in Thailand.

Punchalee Mungkalasut, Patcharakorn Kiatamornrak, Watcharapong Jugnam-Ang, Srivicha Krudsood, Poonlarp Cheepsunthorn, Chalisa Louicharoen Cheepsunthorn

Open access · goldAbstract read
In one paragraph

Article in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Punchalee MungkalasutInterdisciplinary Programme of Biomedical Sciences, Graduate School, Chulalongkorn University, Bangkok, Thailand.
Patcharakorn KiatamornrakMedical Biochemistry Programme, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Watcharapong Jugnam-AngMedical Biochemistry Programme, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Srivicha KrudsoodDepartment of Tropical Hygiene and Clinical Malaria Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Poonlarp CheepsunthornDepartment of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chalisa Louicharoen CheepsunthornDepartment of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Rd., Pathumwan, Bangkok, 10330, Thailand. chalisa.l@chula.ac.th.
Chulalongkorn University · THMahidol Oxford Tropical Medicine Research Unit · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PKLR) deficiencies are common causes of erythrocyte haemolysis in the presence of antimalarial drugs such as primaquine and tafenoquine. The present study aimed to elucidate such an association by thoroughly investigating the haematological indices in malaria patients with G6PD and PKLR

methodsBlood samples from 255 malaria patients from Thailand, Myanmar, Laos, and Cambodia were collected to determine haematological profile, G6PD enzyme activity and G6PD deficiency variants. The multivariate analysis was performed to investigate the association between anaemia and G6PD Mahidol

resultsThe prevalence of G6PD deficiency was 11.1% (27/244) in males and 9.1% (1/11) in female. The MAFs of the G6PD Mahidol

conclusionsThis study revealed that malaria patients with G6PD Mahidol

Indexed as

AntimalarialsGlucosephosphate Dehydrogenase DeficiencyHemoglobinopathiesMalariaMalaria, VivaxCross-Sectional StudiesErythrocytesFemaleGlucosephosphate DehydrogenaseHumansMalePrimaquinePyruvate KinaseThailandAntimalarialsGlucosephosphate DehydrogenasePKLR protein, humanPrimaquinePyruvate KinaseErythrocyte enzymopathyG6PD deficiencyG6PD MahidolPlasmodium falciparumPlasmodium vivaxPyruvate kinaseSoutheast AsianThailand

Identifiers

PMID36038921
PMCPMC9426002
OpenAlexW4293679384

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.