ArticleAging clinical and experimental research2022
Potentially inappropriate medications are negatively associated with functional recovery in patients with sarcopenia after stroke.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Japanese Anticholinergic Risk Scale and Domain-Specific Functional Outcomes in Older Poststroke Patients.Geriatrics & gerontology international · 2026Article
- Medication Reduction is Associated with Improved Activities of Daily Living and Muscle Strength in Post-Stroke Patients with Polypharmacy.JMA journal · 2026Article
- The Dubousset functional test: a reliable and validated physical function and balance assessment tool for older Chinese adults.BMC geriatrics · 2025Article
- The Association between Sarcopenia and Constipation Onset in Community-dwelling Older Adults in Japan.Internal medicine (Tokyo, Japan) · 2025Article
- Psychotropic polypharmacy impairs walking independence in post-stroke patients.European journal of clinical pharmacology · 2025Article
- Article
- Pharmacotherapy in Geriatric Rehabilitation: A Paradigm Shift from Disease Management to Functional Enhancement.Progress in rehabilitation medicine · 2025Article
- Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions.Biomedicines · 2024Review
- Polypharmacy, Potentially Inappropriate Medications, and Dysphagia in Older Inpatients: A Multi-Center Cohort Study.Annals of geriatric medicine and research · 2024Article
- Drug-related sarcopenia as a secondary sarcopenia.Geriatrics & gerontology international · 2024Review
- Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions.Aging and disease · 2024Review
- Associations between Baseline Hyponatremia and Activities of Daily Living and Muscle Health in Convalescent Stroke Patients.Progress in rehabilitation medicine · 2024Article
- Polypharmacy and Its Association with Dysphagia and Malnutrition among Stroke Patients with Sarcopenia.Nutrients · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence is scarce for potentially inappropriate medications (PIMs) in rehabilitation medicine.
aimTo examine the effect of PIMs on functional recovery in older patients with sarcopenia after stroke.
methodsWe conducted a retrospective cohort study in a post-acute rehabilitation hospital. All patients diagnosed with sarcopenia aged ≥ 65 years among all post-stroke patients hospitalized from 2015 to 2020 were included. PIMs were defined based on the 2019 Beers criteria. Sarcopenia was diagnosed using handgrip strength (HG) and skeletal muscle mass index (SMI), according to the criteria of the Asian Working Group for Sarcopenia 2019. The outcomes included functional independence measure motor (FIM-motor), HG, and SMI values at discharge. Multiple linear regression analyses were used to determine whether PIMs used at admission were independently associated with outcomes.
resultsOf the eligible patients, 361 were 65 years or older, of whom 196 (mean age 81.0 years, 44.4% male) presented with sarcopenia and were included in the analysis. Of these, 131 (66.8%) were prescribed PIMs at admission. The most frequently prescribed PIMs were proton pump inhibitors, antipsychotics, benzodiazepines, and nonsteroidal anti-inflammatory drugs. The number of PIMs on admission was independently associated with FIM-motor (β = - 0.132, P = 0.001) and HG (β = - 0.091, P = 0.048) at discharge, but not with SMI (β = - 0.055, P = 0.256).
conclusionsHigh admission PIMs prescription numbers are negatively associated with favorable discharge functional status and muscle strength in older patients with sarcopenia after stroke.
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