Evidence map›Paper›PMID 36038794›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2022

Risk Factors and Mechanisms of Cardiovascular Diseases in Posttraumatic Stress Disorder Model in Wistar Rats as Dependent on Stress Resistance and Age.

M V Kondashevskaya, V E Tseilikman, M V Komelkova, P N Popkov, M S Lapshin, P O Platkovskii, O B Tseilikman, S A Fedorov, M V Chereshneva, V A Chereshnev

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

M V KondashevskayaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia. marivladiko@mail.ru.
V E TseilikmanSouth Ural State University (National Research University), Chelyabinsk, Russia.
M V KomelkovaSouth Ural State University (National Research University), Chelyabinsk, Russia.
P N PopkovSouth Ural State Medical University, Chelyabinsk, Russia.
M S LapshinSouth Ural State University (National Research University), Chelyabinsk, Russia.
P O PlatkovskiiSouth Ural State University (National Research University), Chelyabinsk, Russia.
O B TseilikmanSouth Ural State University (National Research University), Chelyabinsk, Russia.
S A FedorovSouth Ural State University (National Research University), Chelyabinsk, Russia.
M V ChereshnevaInstitute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia.
V A ChereshnevInstitute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia.
South Ural State University · RUInstitute of Immunology and Physiology · RUChelyabinsk State Medical Academy · RUResearch Institute of Human Morphology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The article focuses on the pathogenetic mechanisms of posttraumatic stress disorder (PTSD), which is associated with psychological stress because of the coronavirus pandemic. The molecular mechanisms responsible for disease susceptibility in some individuals and stress resistance in others are amongst crucial research interests of experimental and clinical medicine. Priority data were obtained to indicate that distortions of synthesis and metabolism and, most significantly, a switch between two energy transport forms, glucose and lipids, underlie myocardial dysfunction in young and old stress-sensitive Wistar rats in a PTSD model. Histochemistry and polarization microscopy showed energy deficit in cardiomyocytes and signs of ischemic and hypoxic areas emerging in the myocardium as a result of an accumulation of NADH and NADPH, which initiate excessive production of reactive oxygen species.

Indexed as

Cardiovascular DiseasesStress Disorders, Post-TraumaticAnimalsMyocardiumRatsRats, WistarRisk Factorsmyocardiumposttraumatic stress disorderstress resistancestress sensitivitytransport forms of energyWistar rats

Identifiers

PMID36038794
PMCPMC9423693
OpenAlexW4293503433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.