Evidence map›Paper›PMID 36038752›Full record

ArticleCEN case reports2023

A case of malignant nephrosclerosis occurring with serum renin in the normal range.

Masato Sawamura, Naoki Sawa, Yoichi Oshima, Daisuke Ikuma, Masayuki Yamanouchi, Noriko Hayami, Akinari Sekine, Hiroki Mizuno, Eiko Hasegawa, Tatsuya Suwabe and 5 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Masato SawamuraNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.ORCID 0000-0002-4763-6124
Naoki SawaNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Yoichi OshimaNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Daisuke IkumaNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Masayuki YamanouchiNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Noriko HayamiNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Akinari SekineNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Hiroki MizunoNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Eiko HasegawaNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Tatsuya SuwabeNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Junichi HoshinoNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan.
Kei KonoDepartment of Pathology, Toranomon Hospital, Tokyo, Japan.
Keiichi KinowakiDepartment of Pathology, Toranomon Hospital, Tokyo, Japan.
Kenichi OhashiDepartment of Pathology, Toranomon Hospital, Tokyo, Japan.
Yoshifumi UbaraNephrology Center and Department of Rheumatology, Toranomon Hospital, Kajigaya, 1-3-1, Takatsu, Kawasaki, Tokyo, Kanagawa, 212-0015, Japan. ubara@toranomon.gr.jp.
Toranomon Hospital · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 37-year-old Japanese man was admitted to our hospital for evaluation of severe hypertension and visual impairment. His serum creatinine was 4.16 mg/dL. Plasma renin activity was normal (2.7 ng/mL/h), but plasma aldosterone concentration was elevated (27.2 ng/dL). A kidney biopsy showed concentric subendothelial edematous thickening of the arterioles (onion skin pattern) with luminal narrowing or obstruction, and malignant nephrosclerosis was diagnosed. Antihypertensive therapies, including an angiotensin II receptor blocker and spironolactone, were administered and effectively preserved kidney function and normalized blood pressure. This case indicates that hyperaldosteronemia in the presence of normal renin levels might also cause malignant hypertension.

Indexed as

HypertensionNephrosclerosisAdultAldosteroneHumansMaleReference ValuesReninAldosteroneReninHyperaldosteronemiaHyperaldosteronismHypertensive emergencyMalignant hypertensionMalignant nephrosclerosisRenin-angiotensin system

Identifiers

PMID36038752
PMCPMC9892380
OpenAlexW4293679175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.