Evidence map›Paper›PMID 36038622›Full record

ArticleScientific reports2022

Cumulative life course adversity, mental health, and cognition in the UK biobank.

M Künzi, D A Gheorghe, M Kliegel, N Ballhausen, J Gallacher, S Bauermeister

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Early alcohol abstinence symptoms and the role of cumulative adversity.Alcohol, clinical & experimental research · 2025
    Article
  4. Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Childhood and Adulthood Trauma Associate With Cognitive Aging Among Black and White Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

M KünziCognitive Aging Lab, Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont d'Arve 28, 1205, Geneva, Switzerland. Morgane.Kuenzi@unige.ch.
D A GheorgheDepartment of Experimental and Theoretical Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania.
M KliegelCognitive Aging Lab, Faculty of Psychology and Educational Sciences, University of Geneva, Boulevard du Pont d'Arve 28, 1205, Geneva, Switzerland.
N BallhausenDepartment of Developmental Psychology, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.
J GallacherDementias Platform UK, Department of Psychiatry, University of Oxford, Oxford, UK.
S BauermeisterDementias Platform UK, Department of Psychiatry, University of Oxford, Oxford, UK.
Dementias Platform UK · GBFORS – Swiss Centre of Expertise in the Social Sciences · CHTilburg University · NLUniversity of Oxford · GB

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/T033371/1Medical Research Council MR/T0333771Swiss National Science Foundation 51NF40-185901
6 · The paper itself

Abstract

The association between adversity and cognition varies according to the specific adversity, when the adversity was experienced, and the cognitive domains investigated. Disentangling the effect of adversity and the underlying mechanistic pathway is therefore difficult. The association between adversity (i.e., maltreatment) accumulated over the life course and cognitive flexibility, as well as two potential mediators (i.e., intra-individual variability in reaction time and depression) of this association, were investigated. Data stem from the baseline population of the UK Biobank study (N = 73,489, Mdn

Indexed as

Life Change EventsMental HealthAdultAdverse Outcome PathwaysChildChild AbuseCognitionDepressionExecutive FunctionFemaleHumansIncidenceMaleMiddle AgedSurveys and QuestionnairesUnited Kingdom

Identifiers

PMID36038622
PMCPMC9424182
OpenAlexW4293503530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.