ArticleNature communications2022
A brainstem monosynaptic excitatory pathway that drives locomotor activities and sympathetic cardiovascular responses.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Diosgenin activates ERα-dependent PI3K/AKT/GSK3β signaling to enhance brain-derived serotonin and alleviate postmenopausal bone loss.Journal of advanced research · 2026Article
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- Long-term social isolation during adolescence exacerbated cardiac dysfunction after myocardial infarction.Translational psychiatry · 2026Article
- Control of Blood Pressure Variability Across Behavioral States by Brainstem Adrenergic Neurons.Circulation research · 2026Article
- Ascending propriospinal modulation of thoracic sympathetic preganglionic neurons during lumbar locomotor activity.Frontiers in neural circuits · 2026Article
- The activation of catecholamine neurons in the rostral ventrolateral medulla drives ventricular remodeling after myocardial ischemia/reperfusion injury.Basic research in cardiology · 2025Article
- Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise.The Journal of physiology · 2025Article
- "Chronic Cervical Midline Contusion in Rats Disrupts Aerobic, Muscular, and Cardiovascular Function".bioRxiv : the preprint server for biology · 2025Article
- Biomarkers for Predicting Blood Pressure Response to Renal Denervation.Current hypertension reports · 2025Review
- Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement.Scientific reports · 2025Article
- Abnormal cardiovascular control during exercise: Role of insulin resistance in the brain.Autonomic neuroscience : basic & clinical · 2025Review
- Efficacy and neural mechanism of acupuncture for essential hypertension: Study protocol for a randomized clinical trial.PloS one · 2025Article
- Amygdala-hypothalamus-brainstem circuits underlying cardiovascular responses associated with the limits of high-intensity endurance exercise.Frontiers in physiology · 2025Review
- Cardiac-Sympathetic Contractility and Neural Alpha-Band Power: Cross-Modal Collaboration during Approach-Avoidance Conflict.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Adrenergic C1 neurons enhance anxiety via projections to PAG.bioRxiv : the preprint server for biology · 2024Article
- Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone.Cell · 2024Article
- Hypothalamic Orexinergic Neurons Projecting to the Mesencephalic Locomotor Region Are Activated by Voluntary Wheel Running Exercise in Rats.Yonago acta medica · 2024Article
- Lumbar V3 interneurons provide direct excitatory synaptic input onto thoracic sympathetic preganglionic neurons, linking locomotor, and autonomic spinal systems.Frontiers in neural circuits · 2023Article
- Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise including locomotion requires appropriate autonomic cardiovascular adjustments to meet the metabolic demands of contracting muscles, yet the functional brain architecture underlying these adjustments remains unknown. Here, we demonstrate brainstem circuitry that plays an essential role in relaying volitional motor signals, i.e., central command, to drive locomotor activities and sympathetic cardiovascular responses. Mesencephalic locomotor neurons in rats transmit central command-driven excitatory signals onto the rostral ventrolateral medulla at least partially via glutamatergic processes, to activate both somatomotor and sympathetic nervous systems. Optogenetic excitation of this monosynaptic pathway elicits locomotor and cardiovascular responses as seen during running exercise, whereas pathway inhibition suppresses the locomotor activities and blood pressure elevation during voluntary running without affecting basal cardiovascular homeostasis. These results demonstrate an important subcortical pathway that transmits central command signals, providing a key insight into the central circuit mechanism required for the physiological conditioning essential to maximize exercise performance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.