ArticleNature communications2022
Subcortical-cortical dynamical states of the human brain and their breakdown in stroke.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 69 citations in OpenAlex.
- Bilateral effect of acupuncture on cerebrum and cerebellum in ischaemic stroke patients with hemiparesis: a randomised clinical and neuroimaging trial.Stroke and vascular neurology · 2024Trial
- Harmonized Acquisition of Connectome MRI and Clinical Data for Stroke, Parkinson's Disease and Glioma: Delphi-Derived Protocol Recommendations by the European Academy of Neurology.European journal of neurology · 2026Review
- Transcriptomic and Neuroimaging Decoding of Brain-Immune Crosstalk in Thyroid Eye Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The role of connectivity for the degeneracy of the brain's resting state dynamics.Journal of computational neuroscience · 2026Article
- The Spectrum of Motor Disorders in Patients with Chronic Kidney Disease: Pathogenic Mechanisms, Clinical Manifestations, and Therapeutic Strategies.Journal of clinical medicine · 2026Review
- Dynamic Interactions Between Hemispheres Reveal a Compensatory Pathway for Motor Recovery in Moderate-to-Severe Subcortical Stroke.Journal of stroke · 2026Article
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
- Absence of cortical reorganization following an internal capsule stroke in rodents.bioRxiv : the preprint server for biology · 2025Article
- Switching Patterns of Cortical-Subcortical Interaction in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Structural connectome construction using constrained spherical deconvolution in multi-shell diffusion-weighted magnetic resonance imaging.Nature protocols · 2025Review
- Neural repair mechanisms after ischemic stroke.Inflammation and regeneration · 2025Review
- The Connectional Diaschisis and Normalization of Cortical Language Network Dynamics After Basal Ganglia and Thalamus Stroke.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Constraint-Induced Movement Therapy Promotes Contralesional Red Nucleus Plasticity and Increases Bilateral Motor Cortex-to-Red Nucleus Projections After a Large-Area Stroke.Behavioural neurology · 2025Article
- Alterations in the functional connectivity of thalamic subregions after basal ganglia stroke.Frontiers in neurology · 2025Article
- Reconfiguration of brain network dynamics in bipolar disorder: a hidden Markov model approach.Translational psychiatry · 2024Article
- Symmetry breaking organizes the brain's resting state manifold.Scientific reports · 2024Article
- EEG microstate transition cost correlates with task demands.PLoS computational biology · 2024Article
- Exploring the Relationship between Abnormal Communication Efficiency of Cerebral Cortex and Multiple Cognitive Functions in Mild Subcortical Stroke: A Resting-State fMRI Study.Brain sciences · 2024Article
- Transient resting-state salience-limbic co-activation patterns in functional neurological disorders.NeuroImage. Clinical · 2024Article
- Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms controlling dynamical patterns in spontaneous brain activity are poorly understood. Here, we provide evidence that cortical dynamics in the ultra-slow frequency range (<0.01-0.1 Hz) requires intact cortical-subcortical communication. Using functional magnetic resonance imaging (fMRI) at rest, we identify Dynamic Functional States (DFSs), transient but recurrent clusters of cortical and subcortical regions synchronizing at ultra-slow frequencies. We observe that shifts in cortical clusters are temporally coincident with shifts in subcortical clusters, with cortical regions flexibly synchronizing with either limbic regions (hippocampus/amygdala), or subcortical nuclei (thalamus/basal ganglia). Focal lesions induced by stroke, especially those damaging white matter connections between basal ganglia/thalamus and cortex, provoke anomalies in the fraction times, dwell times, and transitions between DFSs, causing a bias toward abnormal network integration. Dynamical anomalies observed 2 weeks after stroke recover in time and contribute to explaining neurological impairment and long-term outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.