Evidence map›Paper›PMID 36038532›Full record

ArticleNature communications2022

Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent.

Liang Dong, Yun-Jun Xu, Cong Sui, Yang Zhao, Li-Bo Mao, Denis Gebauer, Rose Rosenberg, Jonathan Avaro, Ya-Dong Wu, Huai-Ling Gao and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 72 citations in OpenAlex.

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  6. Dehydration-Driven Glass Formation in Aqueous Carbonates.The journal of physical chemistry letters · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 4 countries.

Liang Dong *Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, 230026, China.
Yun-Jun Xu *Department of Radiology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, 230001, China.
Cong Sui *Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, 230026, China.
Yang ZhaoDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, 230026, China.
Li-Bo MaoDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, 230026, China.ORCID 0000-0002-9249-2449
Denis GebauerInstitute of Inorganic Chemistry, Leibniz Universität Hannover, Callinstr. 9, 30167, Hannover, Germany.ORCID 0000-0003-1612-051X
Rose RosenbergPhysical Chemistry, Department of Chemistry, University of Konstanz, Universitätsstr. 10, Konstanz, D-78457, Germany.
Jonathan AvaroScientist - Center for X-ray Analytics, Empa - Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland.
Ya-Dong WuAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, 230009, China.
Huai-Ling GaoDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, 230026, China.ORCID 0000-0001-8908-1967
Zhao PanDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, 230026, China.
Hui-Qin WenDepartment of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Xu YanAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, 230009, China.
Fei LiAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, 230009, China.
Yang LuAnhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, 230009, China. yanglu@hfut.edu.cn.ORCID 0000-0002-8412-809X
Helmut CölfenPhysical Chemistry, Department of Chemistry, University of Konstanz, Universitätsstr. 10, Konstanz, D-78457, Germany. helmut.coelfen@uni-konstanz.de.ORCID 0000-0002-1148-0308
Shu-Hong YuDepartment of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China, Hefei, 230026, China. shyu@ustc.edu.cn.ORCID 0000-0003-3732-1011
University of Science and Technology of China · CNHefei University of Technology · CNUniversity of Konstanz · DEAnhui Medical University · CNLeibniz University Hannover · DESwiss Federal Laboratories for Materials Science and Technology · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amorphous calcium carbonate plays a key role as transient precursor in the early stages of biogenic calcium carbonate formation in nature. However, due to its instability in aqueous solution, there is still rare success to utilize amorphous calcium carbonate in biomedicine. Here, we report the mutual effect between paramagnetic gadolinium ions and amorphous calcium carbonate, resulting in ultrafine paramagnetic amorphous carbonate nanoclusters in the presence of both gadolinium occluded highly hydrated carbonate-like environment and poly(acrylic acid). Gadolinium is confirmed to enhance the water content in amorphous calcium carbonate, and the high water content of amorphous carbonate nanoclusters contributes to the much enhanced magnetic resonance imaging contrast efficiency compared with commercially available gadolinium-based contrast agents. Furthermore, the enhanced T

Indexed as

Contrast MediaGadoliniumAnimalsCalcium CarbonateDogsIonsMagnetic Resonance ImagingRabbitsRatsWaterCalcium CarbonateContrast MediaGadoliniumIonsWater

Identifiers

PMID36038532
PMCPMC9424530
OpenAlexW4293503894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.