Evidence map›Paper›PMID 36038519›Full record

ArticlePaediatric and perinatal epidemiology2023

Early coronavirus disease 2019 restrictive measures and changes in maternal characteristics, use of assisted reproductive technology, and stillbirth.

Sarka Lisonkova, Jeffrey N Bone, Giulia M Muraca, Neda Razaz, Amelie Boutin, Justin S Brandt, Mohamed A Bedaiwy, Cande V Ananth, K S Joseph

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In one paragraph

Article in Paediatric and perinatal epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sarka LisonkovaDepartment of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-1220-310X
Jeffrey N BoneDepartment of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-7704-1677
Giulia M MuracaDepartment of Obstetrics and Gynecology, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Neda RazazClinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1273-0110
Amelie BoutinDepartment of Pediatrics, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada.ORCID 0000-0003-1907-2920
Justin S BrandtDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.ORCID 0000-0002-3194-1087
Mohamed A BedaiwyDepartment of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, British Columbia, Canada.
Cande V AnanthDivision of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.ORCID 0000-0002-0410-2595
K S JosephDepartment of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-2317-5607

Funding

Ambient Air Pollution, Weather, and Placental Abruption (APWA)R01ES033190 · NIEHS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Cande V. Ananth · 2021 to 2026
$3.1M
Cardiovascular Health After Placental Abruption (CHAP)R01HL150065 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ANANTH, CANDE V., KOSTIS, WILLIAM J · 2020 to 2023
$2.8M
NHLBI NIH HHS R01 HL150065NIEHS NIH HHS R01 ES033190
6 · The paper itself

Abstract

backgroundThe initial COVID-19 pandemic response-related effects on conceptions following the use of assisted reproductive technologies (ART), and on changes in the maternal characteristics of women who conceived during the early vs. pre-pandemic period, have been understudied.

objectivesTo examine the effects of ART clinic closures in the United States (US) in March 2020 on the frequency of ART-conceived live births, multiple births and stillbirths; and to describe changes in the characteristics of women who conceived in the early pandemic period.

methodsPopulation-based cohort study including all births in the US from January 2015 to December 2020 (22,907,688 live births; 134,537 stillbirths). Interrupted time series (ITS) methodology was used to estimate rate ratios (RR) of expected versus observed rates in December 2020 (i.e., among births conceived mainly in March 2020). Demographic and clinical characteristics were compared between mothers who conceived in March 2020 versus March 2015-2019.

resultsOverall, 1.1% of live births and 1.7% of stillbirths were conceived by ART. ART-conceived live births decreased by 57.0% in December 2020 (observed vs. expected RR 0.43, 95% confidence interval [CI] 0.40, 0.45), and these declines occurred in all subgroups of women. Multiple births also declined in December 2020. Stillbirth rates increased in December 2020 in ART-conceived births (RR 2.55, 95% CI 1.63, 3.92) but remained unchanged in the non-ART group. Maternal characteristics of women who conceived in the early pandemic versus pre-pandemic period differed and included an increased prevalence of pre-pregnancy obesity class 3 and chronic hypertension.

conclusionsThe early pandemic closure of ART clinics resulted in a substantial decline in ART-conceived live births and multiple births in December 2020 and an increase in the proportion of stillbirths among ART-conceived births. Women who conceived in the early pandemic period also had an increased prevalence of obesity and chronic hypertension.

Indexed as

COVID-19HypertensionPremature BirthCohort StudiesFemaleHumansInfant, Low Birth WeightInfant, NewbornInfant, PrematureObesityPandemicsPopulation SurveillancePregnancyPregnancy OutcomeReproductive Techniques, AssistedStillbirthassisted reproductive technologyconceptioncoronavirus disease 2019multiple birthpandemic responsestillbirth

Identifiers

PMID36038519
PMCPMC9539106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.