Evidence map›Paper›PMID 36038379›Full record

ArticleBiological psychiatry2022

Putamen Structure and Function in Familial Risk for Depression: A Multimodal Imaging Study.

Ardesheer Talati, Milenna T van Dijk, Lifang Pan, Xuejun Hao, Zhishun Wang, Marc Gameroff, Zhengchao Dong, Jürgen Kayser, Stewart Shankman, Priya J Wickramaratne and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ardesheer TalatiDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York. Electronic address: adi.talati@nyspi.columbia.edu.
Milenna T van DijkDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.
Lifang PanDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.
Xuejun HaoDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.
Zhishun WangDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Imaging, New York State Psychiatric Institute, New York, New York.
Marc GameroffDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.
Zhengchao DongDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York.
Jürgen KayserDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.
Stewart ShankmanDepartment of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois.
Priya J WickramaratneDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, New York.
Jonathan PosnerDepartment of Psychiatry, Duke University, Durham, North Carolina.
Myrna M WeissmanDepartment of Psychiatry, Columbia University Irving Medical Center and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York.

Funding

Three Generations at High and Low Risk for Depression Followed LongitudinallyR01MH036197 · NIMH · YALE UNIVERSITY · PI POSNER, JONATHAN E, WEISSMAN, MYRNA M · 1985 to 2020
$15.0M
Hippocampal and Genetic Mechanisms Underlying Development of Depression in Children at High Family RiskK99MH129611 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI VAN DIJK, MILENNA TAMARA · 2022 to 2023
$255k
NIMH NIH HHS K99 MH129611NIMH NIH HHS R01 MH036197
6 · The paper itself

Abstract

backgroundThe putamen has been implicated in depressive disorders, but how its structure and function increase depression risk is not clearly understood. Here, we examined how putamen volume, neuronal density, and mood-modulated functional activity relate to family history and prospective course of depression.

methodsThe study includes 115 second- and third-generation offspring at high or low risk for depression based on the presence or absence of major depressive disorder in the first generation. Offspring were followed longitudinally using semistructured clinical interviews blinded to their familial risk; putamen structure, neuronal integrity, and functional activation were indexed by structural magnetic resonance imaging (MRI), proton magnetic resonance spectroscopy (N-acetylaspartate/creatine ratio), and functional MRI activity modulated by valence and arousal components of a mood induction task, respectively.

resultsAfter adjusting for covariates, the high-risk individuals had lower putamen volume (standardized betas, β-

conclusionsFindings demonstrate abnormalities in putamen structure and function in individuals at high risk for major depressive disorder. Future studies should focus on this region as a potential biomarker for depressive illness, noting meanwhile that differences attributable to family history may peak at different ages based on which MRI modality is being used to assay them.

Indexed as

Major Depressive DisorderPutamenCreatineDepressionGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMultimodal ImagingProspective StudiesCreatineHigh-riskMagnetic resonance imaging (MRI)Magnetic resonance spectroscopy (MRS)Major depressive disorder (MDD)Multimodal imagingPutamenResearch Domain Criteria (RDoC)

Identifiers

PMID36038379
PMCPMC9872322

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.