Observational studyThe clinical respiratory journal2022
Factors associated with failure of using high flow nasal cannula in children.
Observational study in The clinical respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06146439 (Determination of the Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula Due to Moderate and Severe Respiratory Distress), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determination of the Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula Due to Moderate and Severe Respiratory Distress
Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Risk factors and outcomes of pediatric non-invasive respiratory support failure in Latin America.Journal of intensive medicine · 2025Article
- Observational
- Utilization of High-Flow Nasal Cannulas in Pediatric Critical Care: A Single-Center Experience.Cureus · 2024Article
- Factors associated with failure of using high flow nasal cannula in children.The clinical respiratory journal · 2022Observational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionHigh flow nasal cannula (HFNC) has significantly success in treating acute respiratory distress while HFNC failure dramatically increases mortality and morbidity.
objectiveTo describe factors associated with failure of HFNC use in children.
methodsWe performed a retrospective observational study using demographic and laboratory findings. We compared clinical and laboratory variables in both successful and failed HFNC groups. The correlations between factors and HFNC failure were constructed by binary logistic regression analysis.
resultsBetween August 2016 and May 2018, 250 children receiving HFNC (median age 16 months; range 1-228 months, male 50.8%) were enrolled. Pneumonia was the most common cause of respiratory distress, and the median length of stay (LOS) in hospital was 11 days. HFNC failure was found 16.4% while HFNC complication was 4.8% including epistaxis, pressure sore, and gastric distension. Based on multivariable logistic regression analysis, factors associated with HFNC failure were children with congenital heart disease comorbidity (p = 0.005), HFNC use with maximum FiO
conclusionHFNC is feasible to use for children with respiratory distress; however, patients with congenital heart disease, using HFNC with FiO
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Registered trials
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