Evidence map›Paper›PMID 36038274›Full record

ArticleNeurology2022

Incidence and Time Trends of Pregnancy-Related Stroke Between 2010 and 2018: The Nationwide CONCEPTION Study.

Alice Martin, Grégory Lailler, Yannick Béjot, Amélie Gabet, Clémence Grave, Nolwenn Regnault, Edouard Chatignoux, Elodie Moutengou, Catherine Deneux-Tharaux, Sandrine Kretz and 5 more

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In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Neurologic Complications of Pregnancy and Menopause.Continuum (Minneapolis, Minn.) · 2026
    Review
  5. Article
  6. Article
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  12. Observational
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Alice MartinFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.
Grégory LaillerFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.ORCID 0000-0001-6838-8804
Yannick BéjotFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.ORCID 0000-0002-2749-857X
Amélie GabetFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.ORCID 0000-0003-1273-8988
Clémence GraveFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.ORCID 0000-0002-2843-1510
Nolwenn RegnaultFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.ORCID 0000-0002-0781-1450
Edouard ChatignouxFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.
Elodie MoutengouFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.
Catherine Deneux-TharauxFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.ORCID 0000-0002-6561-3321
Sandrine KretzFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.
Claire Mounier-VehierFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.ORCID 0000-0001-9407-0701
Vassilis TsatsarisFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.ORCID 0000-0002-7650-6660
Genevieve Plu-BureauFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.ORCID 0000-0002-1020-8142
Jacques BlacherFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France.
Valérie OliéFrom the French Public Health Agency (A.M., G.L., A.G., C.G., N.R., E.C., E.M., V.O.), Saint-Maurice; Dijon Stroke Registry (Y.B.), University Hospital and Medical School of Dijon, University of Burgundy; Inserm U1153 (C.D.-T., G.P.-B.), Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS); Paris-Descartes University (C.D.-T., V.T., G.P.-B., J.B.); Diagnosis and Therapeutic Center (S.K., J.B.), Hotel Dieu, AP-HP, University Paris Descartes; Vascular Medecine and Hypertension Center (C.M.-V.), EA 2694, Santé Publique, University Lille; Department of Obstetrics and Gynecology (V.T.), APHP, Port-Royal Maternity, University Hospital Center Cochin Broca Hôtel Dieu, Groupe Hospitalier Universitaire Ouest; and Division of Gynaecology (G.P.-B.), APHP, Hôpital Cochin, Paris, France. valerie.olie@santepubliquefrance.fr.
Délégation Paris 5 · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesDespite the potentially devastating effects of pregnancy-related stroke, few studies have examined its incidence by type of stroke. We aimed to study the nationwide incidence rates and recent temporal trends for all types of pregnancy-related stroke and to compare these incidences with stroke incidence in nonpregnant women.

methodsWe conducted a study of 6,297,698 women aged 15-49 years who gave birth in France between 2010 and 2018 with no history of stroke before pregnancy by collecting data from the French National Health Insurance Information System database. Poisson regression was used to estimate the incidence by types of strokes for the different pregnancy periods and the incidence rate ratio of stroke in pregnant vs nonpregnant French women.

resultsAmong the 6,297,698 women, 1,261 (24.0 per 100,000 person-years) experienced a first ever stroke during, antepartum peripartum, or the first 6 weeks of postpartum. Of the pregnancy-related strokes, 42.9% were ischemic (IS), 41.9% were hemorrhagic (with similar proportion of intracerebral and subarachnoid hemorrhage), and 17.4% were cerebral venous thrombosis (CVT). Compared with nonpregnant women, incidence rates of stroke were similar during pregnancy for IS (adjusted incidence risk ratio [IRR] 0.9 [0.8-1.1]), slightly higher for all hemorrhagic strokes (IRR 1.4 [1.2-1.8]), and considerably increased for CVT (IRR 8.1 [6.5-10.1]). Pregnancy-related stroke incidence rose between 2010 and 2018 for IS and HS but was stable for CVT. DISCUSSION: The risk of pregnancy-related CVT was more than 8-fold higher than that observed in nonpregnant women. The incidence of pregnancy-related IS and HS is increasing over time, and efforts should be made for prevention considering treatable cardiovascular risk factors and hypertensive disorders in pregnant women.

Indexed as

Intracranial ThrombosisPregnancy Complications, CardiovascularStrokeSubarachnoid HemorrhageFemaleHumansIncidencePregnancyRisk Factors

Identifiers

PMID36038274
PMCPMC9559943
OpenAlexW4293731893

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