Evidence map›Paper›PMID 36038137›Full record

ArticleNano letters2022

Near-Infrared Carbon Nanotube Tracking Reveals the Nanoscale Extracellular Space around Synapses.

Chiara Paviolo, Joana S Ferreira, Antony Lee, Daniel Hunter, Ivo Calaresu, Somen Nandi, Laurent Groc, Laurent Cognet

Open access · hybridAbstract read
In one paragraph

Article in Nano letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Visualising sub-second dynamics of nanoparticle extravasationbioRxiv : the preprint server for biology · 2025
    Article
  5. Near-Infrared Fluorescent Single-Walled Carbon Nanotubes for Biosensing.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chiara PavioloUniversité de Bordeaux, Institut d'Optique & Centre National de la Recherche Scientifique, UMR 5298, 33400 Talence, France.
Joana S FerreiraUniversité de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France.
Antony LeeUniversité de Bordeaux, Institut d'Optique & Centre National de la Recherche Scientifique, UMR 5298, 33400 Talence, France.ORCID 0000-0003-2193-5369
Daniel HunterUniversité de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France.
Ivo CalaresuUniversité de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France.
Somen NandiUniversité de Bordeaux, Institut d'Optique & Centre National de la Recherche Scientifique, UMR 5298, 33400 Talence, France.
Laurent GrocUniversité de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France.
Laurent CognetUniversité de Bordeaux, Institut d'Optique & Centre National de la Recherche Scientifique, UMR 5298, 33400 Talence, France.ORCID 0000-0002-3573-5387
Université de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We provide evidence of a local synaptic nanoenvironment in the brain extracellular space (ECS) lying within 500 nm of postsynaptic densities. To reveal this brain compartment, we developed a correlative imaging approach dedicated to thick brain tissue based on single-particle tracking of individual fluorescent single wall carbon nanotubes (SWCNTs) in living samples and on speckle-based HiLo microscopy of synaptic labels. We show that the extracellular space around synapses bears specific properties in terms of morphology at the nanoscale and inner diffusivity. We finally show that the ECS juxta-synaptic region changes its diffusion parameters in response to neuronal activity, indicating that this nanoenvironment might play a role in the regulation of brain activity.

Indexed as

Nanotubes, CarbonBrainExtracellular SpaceSingle Molecule ImagingSynapsesNanotubes, Carbonbrain extracellular spacecorrelative imagingorganotypic brain slicessingle particle trackingSingle-walled carbon nanotubessuperlocalization microscopysynapses

Identifiers

PMID36038137
PMCPMC9479209
OpenAlexW4293510503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.