Evidence map›Paper›PMID 36037637›Full record

ReviewCurrent opinion in microbiology2022

Antifungal discovery.

Nicole Robbins, Leah E Cowen

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. HTD1265 Disrupts GimC-Dependent Cellular Processes inPathogens (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Molecular mechanisms governing antifungal drug resistance.npj antimicrobials and resistance · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: leah.cowen@utoronto.ca.

Funding

Targeting Hsp90 in cryptococcal fungal pathogenesisR01AI165466 · NIAID · UNIVERSITY OF TORONTO · PI Lauren Elaine Brown, LEAH Elizabeth Cowen · 2022 to 2026
$3.2M
Targeting Hsp90 in cryptococcal fungal pathogenesisR01AI120958 · NIAID · UNIVERSITY OF TORONTO · PI BROWN, LAUREN ELAINE, COWEN, LEAH ELIZABETH · 2016 to 2019
$3.2M
Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesisR01AI162789 · NIAID · UNIVERSITY OF TORONTO · PI LEAH Elizabeth Cowen, Timothy M Willson · 2022 to 2026
$3.1M
NIAID NIH HHS R01 AI120958NIAID NIH HHS R01 AI162789NIAID NIH HHS R01 AI165466
6 · The paper itself

Abstract

Fungi have a profound impact on human health, leading to billions of infections and millions of deaths worldwide each year. Exacerbating the public health burden is the continued emergence of drug-resistant fungal pathogens coupled with a dearth of treatment options to combat serious infections. Despite this health threat, scientific advances in chemistry, genetics, and biochemistry methodologies have enabled novel antifungal compounds to be discovered. Here, we describe current approaches for the discovery and characterization of novel antifungals, focusing on the identification of novel chemical matter and elucidation of the cellular target of bioactive compounds, followed by a review of the most promising emerging therapies in the antifungal-development pipeline.

Indexed as

Antifungal AgentsDrug Resistance, FungalFungiHumansAntifungal Agents

Identifiers

PMID36037637
PMCPMC10726697

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.