Evidence map›Paper›PMID 36037480›Full record

ArticleJournal of virology2022

Testosterone Promotes the Intestinal Replication and Dissemination of Coxsackievirus B3 in an Oral Inoculation Mouse Model.

Adeeba H Dhalech, Caleb M Corn, Vrushali Mangale, Fahim Syed, Stephanie A Condotta, Martin J Richer, Christopher M Robinson

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. A viral-specific CD4Frontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Adeeba H Dhalech *Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Caleb M Corn *Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Vrushali MangaleDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Fahim SyedDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Stephanie A CondottaDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Martin J RicherDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Christopher M RobinsonDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-4086-4690
Indiana University School of Medicine

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
Immunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0M
Sex-dependent replication of coxsackievirusK01DK110216 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ROBINSON, CHRISTOPHER MICHAEL · 2016 to 2021
$732k
Contribution of host genetic factors to intestinal Coxsackievirus replicationR03DK124749 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ROBINSON, CHRISTOPHER MICHAEL · 2020 to 2021
$229k
NCI NIH HHS P30 CA082709NIAID NIH HHS T32 AI060519NIDDK NIH HHS K01 DK110216NIDDK NIH HHS R03 DK124749NIDDK NIH HHS U54 DK106846
6 · The paper itself

Abstract

Enteroviruses initiate infection in the gastrointestinal tract, and sex is often a biological variable that impacts pathogenesis. Previous data suggest that sex hormones can influence the intestinal replication of Coxsackievirus B3 (CVB3), an enterovirus in the

Indexed as

AnimalsCoxsackievirus InfectionsDisease Models, AnimalFemaleHost-Pathogen InteractionsMaleMiceTestosteroneVirus ReplicationTestosteroneCoxsackievirus B3sex biassex hormonestestosterone

Identifiers

PMID36037480
PMCPMC9472648
OpenAlexW4293679311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.