Evidence map›Paper›PMID 36037447›Full record

ArticleJournal of medicinal chemistry2022

Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors.

Sneha Basak, Yong Li, Suyuan Tao, Fereidoon Daryaee, Jonathan Merino, Chendi Gu, Silvia L Delker, Jenny N Phan, Thomas E Edwards, Stephen G Walker and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Selectivity of the Time-DependentACS chemical biology · 2025
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Sneha Basak
Yong Li
Suyuan TaoORCID 0000-0003-2482-4402
Fereidoon Daryaee
Jonathan Merino
Chendi Gu
Silvia L DelkerUCB, 87 Cambridge Park Drive, Cambridge, Massachusetts 01240, United States.
Jenny N PhanMcGill University, Montreal, Quebec H3A 0G4, Canada.
Thomas E EdwardsUCB, 7869 NE Day Road, West Bainbridge Island, Washington 98110, United States.ORCID 0000-0002-0474-8003
Stephen G Walker
Peter J TongeORCID 0000-0003-1606-3471
Stony Brook University · USMcGill University · CAUrban College of Boston · US

Funding

Establishing a Long Island Bioscience HubU01HL127522 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI RUBIN, CLINTON T · 2015 to 2017
$3.0M
Mechanism of Slow Onset Enzyme Inhibition and Translation to Time-Dependent Drug ActivityR01GM102864 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI TONGE, PETER J · 2012 to 2021
$2.6M
NHLBI NIH HHS U01 HL127522NIAID NIH HHS HHSN272201700059CNIGMS NIH HHS R01 GM102864
6 · The paper itself

Abstract

UDP-3-

Indexed as

AmidohydrolasesPseudomonas aeruginosaAnti-Bacterial AgentsEnzyme InhibitorsGram-Negative BacteriaKineticsAmidohydrolasesAnti-Bacterial AgentsEnzyme Inhibitors

Identifiers

PMID36037447
PMCPMC10182817
OpenAlexW4293498983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.