Evidence map›Paper›PMID 36037402›Full record

ArticleVeterinary medicine and science2022

Blood-brain barrier permeability to enrofloxacin in Pengze crucian carp (Carassius auratus var. Pengze).

Fan Zhang, Runping Wang, Jianzhen Huang, Haixin Zhang, Long Wang, Zhiwei Zhong, Jiming Ruan, Huazhong Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary medicine and science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Fan ZhangDepartment of Aquaculture, College of Animal Science & Technology, Jiangxi Agricultural University, Nanchang, P.R. China.
Runping WangDepartment of Aquaculture, College of Animal Science & Technology, Jiangxi Agricultural University, Nanchang, P.R. China.
Jianzhen HuangDepartment of Aquaculture, College of Animal Science & Technology, Jiangxi Agricultural University, Nanchang, P.R. China.
Haixin ZhangJiangxi Fisheries Research Institute, Nanchang, P.R. China.
Long WangBureau of Agriculture and Rural Affairs of Pengze County, Pengze, P.R. China.
Zhiwei ZhongDepartment of Aquaculture, College of Animal Science & Technology, Jiangxi Agricultural University, Nanchang, P.R. China.
Jiming RuanDepartment of Aquaculture, College of Animal Science & Technology, Jiangxi Agricultural University, Nanchang, P.R. China.
Huazhong LiuCollege of Chemistry & Environmental Science, Guangdong Ocean University, Zhanjiang, P.R. China.ORCID 0000-0003-3568-1697
Jiangxi Agricultural University · CNGuangdong Ocean University · CNJiangxi Fisheries Research Institute · CNMinistry of Agriculture and Rural Affairs · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnrofloxacin (ENR) is a kind of quinolone antibiotic that is most widely used antimicrobials in veterinary practice, and possesses both a broad spectrum antimicrobial activity against a range of bacteria and adverse effects towards plants and animals.

objectivesThis study was conducted to explore the permeability of blood-brain barrier (BBB) to ENR and brain injury based on crucian carp orally administrated with high dose of ENR.

methodsJuvenile Pengze crucian carp were treated with half lethal dose (LD

resultsData indicated that ENR destroyed BBB structure of crucian carp and enhanced permeability of the biological barrier, resulting in more ENR crossed BBB and induced brain damage of crucian carp.

conclusionsThis data indicated that ENR can induce brain damage of crucian carp through destroying BBB structure and enhancing permeability.

Indexed as

CarpsGoldfishAnimalsBlood-Brain BarrierEnrofloxacinPermeabilityEnrofloxacinblood-brain barrierdrug residuesenrofloxacinPengze crucian carp

Identifiers

PMID36037402
PMCPMC9677365
OpenAlexW4293484259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.