Evidence map›Paper›PMID 36037353›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Different classes of genomic inserts contribute to human antibody diversity.

Mikhail Lebedin, Mathilde Foglierini, Svetlana Khorkova, Clara Vázquez García, Christoph Ratswohl, Alexey N Davydov, Maria A Turchaninova, Claudia Daubenberger, Dmitriy M Chudakov, Antonio Lanzavecchia and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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  7. Orientation Regulation of Class-switch Recombination in Human B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 5 countries.

Mikhail LebedinMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0002-3877-7195
Mathilde FoglieriniInstitute for Research in Biomedicine, Università della Svizzera Italiana, Via Francesco Chiesa 5, 6500 Bellinzona, Switzerland.
Svetlana KhorkovaMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0002-7873-2290
Clara Vázquez GarcíaMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0003-4583-7616
Christoph RatswohlMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0001-5413-0730
Alexey N DavydovCentral European Institute of Technology, Masaryk University, 601 77 Brno, Czech Republic.
Maria A TurchaninovaDepartment of Genomics of Adaptive Immunity, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russian Federation.ORCID 0000-0002-8874-0286
Claudia DaubenbergerDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.ORCID 0000-0001-7136-0642
Dmitriy M ChudakovDepartment of Genomics of Adaptive Immunity, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russian Federation.ORCID 0000-0003-0430-790X
Antonio LanzavecchiaInstitute for Research in Biomedicine, Università della Svizzera Italiana, Via Francesco Chiesa 5, 6500 Bellinzona, Switzerland.
Kathrin de la RosaMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0003-4809-3157
Max Delbrück Center · DECentral European Institute of Technology · CZPirogov Russian National Research Medical University · RUSwiss Tropical and Public Health Institute · CHUniversità della Svizzera italiana · CHYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombination of antibody genes in B cells can involve distant genomic loci and contribute a foreign antigen-binding element to form hybrid antibodies with broad reactivity for

Indexed as

Antibody DiversityB-LymphocytesGenes, ImmunoglobulinAntibodies, ProtozoanAntigens, CDGenomicsHumansImmunoglobulin Light ChainsLeukocyte Immunoglobulin-like Receptor B1Mutagenesis, InsertionalPlasmodium falciparumReceptors, Antigen, T-CellReceptors, ImmunologicAntibodies, ProtozoanAntigens, CDImmunoglobulin Light Chainsleukocyte-associated immunoglobulin-like receptor 1Leukocyte Immunoglobulin-like Receptor B1LILRB1 protein, humanReceptors, Antigen, T-CellReceptors, Immunologicantibody repertoireB cell diversityinsert

Identifiers

PMID36037353
PMCPMC9457163
OpenAlexW4293484512

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.