Evidence map›Paper›PMID 36037034›Full record

ArticleChemphyschem : a European journal of chemical physics and physical chemistry2022

Low-boiling Point Perfluorocarbon Nanodroplets as Dual-Phase Dual-Modality MR/US Contrast Agent.

Christian T McHugh, Phillip G Durham, Sebastian Atalla, Michele Kelley, Nicholas J Bryden, Paul A Dayton, Rosa T Branca

Open access · hybridAbstract read
In one paragraph

Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Low-boiling Point Perfluorocarbon Nanodroplets as Dual-Phase Dual-Modality MR/US Contrast Agent.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022
    Article
  4. Life at the interface: Engineering bio-nanomaterials through interfacial molecular self-assembly.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christian T McHughDepartment of Physics & Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, US.ORCID 0000-0001-5668-2088
Phillip G DurhamDepartment of Pharmacoengineering and Molecular Pharmaceutics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sebastian AtallaDepartment of Physics & Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, US.
Michele KelleyDepartment of Physics & Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, US.
Nicholas J BrydenDepartment of Physics & Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, US.
Paul A DaytonBiomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Rosa T BrancaDepartment of Physics & Astronomy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, US.ORCID 0000-0002-6871-1824
University of North Carolina at Chapel Hill · US

Funding

Sensitive and Specific detection of BAT Tissue and Activity by Magnetic Resonance with Hyperpolarized Xe-129R01DK108231 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRANCA, ROSA TAMARA · 2015 to 2019
$1.6M
Enabling accurate identification and quantification of brown adipose tissue mass by xenon enhanced computed tomographyR01DK123206 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRANCA, ROSA TAMARA · 2020 to 2021
$866k
Gas microbubbles as a hyperpolarized-xenon carrier and as a contrast agent for MRIR21EB031319 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRANCA, ROSA TAMARA · 2021 to 2022
$413k
NIBIB NIH HHS R21 EB031319NIBIB NIH HHS R21EB031319NIDDK NIH HHS R01 DK108231NIDDK NIH HHS R01 DK123206
6 · The paper itself

Abstract

Detection of bare gas microbubbles by magnetic resonance (MR) at low concentrations typically used in clinical contrast-ultrasound studies was recently demonstrated using hyperCEST. Despite the enhanced sensitivity achieved with hyperCEST, in vivo translation is challenging as on-resonance saturation of the gas-phase core of microbubbles consequently results in saturation of the gas-phase hyperpolarized

Indexed as

FluorocarbonsContrast MediaMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMicrobubblesContrast MediaFluorocarbonsHyperCESTmicrobubblesNMR Spectroscopyperfluorocarbon nanodropletsxenon

Identifiers

PMID36037034
PMCPMC10087365
OpenAlexW4293475213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.