Evidence map›Paper›PMID 36037026›Full record

SynthesisEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2023

Predictors of recurrence after catheter ablation and electrical cardioversion of atrial fibrillation: an umbrella review of meta-analyses.

Emmanouil Charitakis, Elena Dragioti, Maria Stratinaki, Dafni Korela, Stylianos Tzeis, Henrik Almroth, Ioan Liuba, Anders Hassel Jönsson, Georgios Charalambous, Lars O Karlsson and 1 more

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Predictors of atrial fibrillation recurrence after catheter ablation: a systematic review.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
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  9. Pre-procedural time spent in atrial fibrillation using intermittent ECG monitoring is associated with arrhythmia recurrence after ablation: the ISOLATION cohort study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
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  15. Review
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  17. Impact of atrial fibrillation diagnosis-to-ablation time on 24-month efficacy and safety outcomes in the Cryo Global Registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Emmanouil CharitakisDepartment of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping 58185, Sweden.ORCID 0000-0002-2514-5324
Elena DragiotiPain and Rehabilitation Centre and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping 58758, Sweden.ORCID 0000-0001-9019-4125
Maria StratinakiDepartment of Cardiology, Venizeleio General Hospital, Heraklion, Crete 71409, Greece.ORCID 0000-0001-8720-1830
Dafni KorelaDepartment of Cardiology, Venizeleio General Hospital, Heraklion, Crete 71409, Greece.ORCID 0000-0003-0774-4339
Stylianos TzeisMitera Hospital, Hygeia Group, Athens 15123, Greece.ORCID 0000-0002-2007-1928
Henrik AlmrothDepartment of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping 58185, Sweden.ORCID 0000-0003-2618-5966
Ioan LiubaDepartment of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping 58185, Sweden.ORCID 0000-0001-7370-6993
Anders Hassel JönssonDepartment of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping 58185, Sweden.
Georgios CharalambousDepartment of Emergency Medicine, 'Hippokration' Hospital, Athens, Vasilissis Sofias 114, 11527 Athens, Greece.ORCID 0000-0001-6384-732X
Lars O KarlssonDepartment of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping 58185, Sweden.
Dimitrios TsartsalisDepartment of Emergency Medicine, 'Hippokration' Hospital, Athens, Vasilissis Sofias 114, 11527 Athens, Greece.ORCID 0000-0002-7535-938X
Linköping University · SEHippocration General Hospital · GRThe General Hospital of Heraklion "Venizeleio-Pananio" · GRMitera Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe recurrence rates after catheter ablation (CA) and direct current (DC) cardioversion remain high, although they have been established treatments of rhythm control of atrial fibrillation (AF). This umbrella review systematically appraises published meta-analyses of both observational and randomized controlled trials (RCTs) for the association of risk and protective factors for arrhythmia recurrence after CA and DC cardioversion of AF. METHODS AND

resultsThree bibliographic databases were searched up to June 2021. Evidence of association was rated as convincing, highly suggestive, suggestive, weak, or not significant with respect to observational studies and as high, moderate, low, or very low with respect to RCTs, according to established criteria. Thirty-one meta-analyses were included. Of the 28 associations between CA and the risk of arrhythmia recurrence, none presented convincing evidence, and only the time from diagnosis to ablation over 1 year provided highly suggestive evidence. The association between hypertension and metabolic profile provided suggestive evidence. The associations of Class IC and III antiarrhythmic drugs use with the recurrence after DC cardioversion were supported by an intermediate level of evidence.

conclusionAlthough AF is a major health issue, few risk- and protective factors for AF recurrence have been identified. None of these factors examined were supported by convincing evidence, whereas established factors such as female gender and left atrial volume showed only weak association. An early CA strategy combined with treatment of metabolic syndrome and hypertension prior to CA may reduce the risk of arrhythmia recurrence. The use of antiarrhythmics can increase the success rate of DC cardioversion. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registry number: CRD42021270613.

Indexed as

Atrial FibrillationCatheter AblationAnti-Arrhythmia AgentsElectric CountershockFemaleHumansMeta-Analysis as TopicRecurrenceTreatment OutcomeAnti-Arrhythmia AgentsCatheter ablation • Atrial fibrillationElectrical cardioversionUmbrella review

Identifiers

PMID36037026
PMCPMC10103559
OpenAlexW4293475239

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.