Evidence map›Paper›PMID 36036888›Full record

ArticleMolecular pharmaceutics2022

Host-Guest Complexation by β-Cyclodextrin Enhances the Solubility of an Esterified Protein.

Keith M Cheah, Joomyung V Jun, K Dane Wittrup, Ronald T Raines

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Hydrophilic α-Aryl-α-Diazoamides for Protein Esterification.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Keith M Cheah
K Dane Wittrup
Massachusetts Institute of Technology · US

Funding

STRUCTURE--FUNCTION ANALYSIS OF RIBONUCLEASE AR01GM044783 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI RAINES, RONALD T · 1990 to 2021
$7.1M
Localized immunotherapy using alum-binding therapeuticsR01EB031082 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IRVINE, DARRELL J, WITTRUP, KARL DANE · 2021 to 2024
$2.1M
NIBIB NIH HHS R01 EB031082NIGMS NIH HHS R01 GM044783
6 · The paper itself

Abstract

The carboxyl groups of a protein can be esterified by reaction with a diazo compound, 2-diazo-2-(

Indexed as

beta-CyclodextrinsCyclodextrinsAnimalsEsterificationEstersExcipientsMammalsSolubilitybeta-CyclodextrinsCyclodextrinsEstersExcipientsdiazo compoundencapsulationexcipientprotein esterificationprotein solubilityprotein transduction

Identifiers

PMID36036888
PMCPMC9643614
OpenAlexW4293456941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.