Evidence map›Paper›PMID 36036634›Full record

ArticleMicrobiology spectrum2022

Development of a Glycerol-Inducible Expression System for High-Yield Heterologous Protein Production in Bacillus subtilis.

Laichuang Han, Qiaoqing Chen, Jie Luo, Wenjing Cui, Zhemin Zhou

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Heterologous expression and characterization of a thermostable MprT metalloprotease from thermophilic Bacillus subtilis BSP in dual host systems.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  2. Development of Bacillus subtilis cell factories for nutraceuticals production.World journal of microbiology & biotechnology · 2026
    Review
  3. Metabolic Engineering Strategy forFoods (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laichuang HanSchool of Biotechnology, Jiangnan Universitygrid.258151.a, Wuxi, Jiangsu, China.
Qiaoqing ChenSchool of Biotechnology, Jiangnan Universitygrid.258151.a, Wuxi, Jiangsu, China.
Jie LuoSchool of Biotechnology, Jiangnan Universitygrid.258151.a, Wuxi, Jiangsu, China.
Wenjing CuiSchool of Biotechnology, Jiangnan Universitygrid.258151.a, Wuxi, Jiangsu, China.
Zhemin ZhouSchool of Biotechnology, Jiangnan Universitygrid.258151.a, Wuxi, Jiangsu, China.ORCID 0000-0003-0604-1885
Jiangnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of efficient, low-cost, and robust expression systems is important for the mass production of proteins and natural products in large amounts using cell factories. Glycerol is an ideal carbon source for large-scale fermentation due to its low cost and favorable maintenance of the fermentation process. Here, we used the antiterminator protein GlpP and its target promoter P

Indexed as

Aspartate Ammonia-LyaseBiological Products5' Untranslated RegionsBacillus subtilisCarbonGene Expression Regulation, BacterialGlucoseGlycerol5' Untranslated RegionsAspartate Ammonia-LyaseBiological ProductsCarbonGlucoseGlycerolantiterminator proteinBacillus subtilisglycerol-inducible expression systemhybrid promoternattokinase

Identifiers

PMID36036634
PMCPMC9604022
OpenAlexW4293445896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.