Evidence map›Paper›PMID 36036630›Full record

ArticleAging cell2022

Alterations in high-dimensional T-cell profile and gene signature of immune aging in HIV-infected older adults without viremia.

Min Sun Shin, Hong-Jai Park, Syim Salahuddin, Ruth R Montgomery, Brinda Emu, Albert C Shaw, Insoo Kang

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Observational
  6. Review
  7. Aging gene signature of memory CD8Immunity & ageing : I & A · 2023
    Article
  8. Article
  9. Article
  10. Negative Lifestyle Factors Specific to Aging Persons Living with HIV and Multimorbidity.Journal of the International Association of Providers of AIDS Care
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Min Sun ShinDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Hong-Jai ParkDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Syim SalahuddinDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Ruth R MontgomeryDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Brinda EmuDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Albert C ShawDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Insoo KangDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-7483-1171
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Systems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI Steven H. Kleinstein · 2010 to 2026
$50.4M
The Impact of Aging and HIV Infection on Immunologic and Transcriptomic Signatures of Influenza Vaccine ResponseR01AG055362 · NIA · YALE UNIVERSITY · PI KANG, INSOO, SHAW, ALBERT C · 2017 to 2021
$4.0M
Studying the impact of altered CD8+ T cell immunity in Alzheimer's diseaseR01AG056728 · NIA · YALE UNIVERSITY · PI KANG, INSOO · 2018 to 2022
$2.3M
Midcareer Award in Translational Immunology of AgingK24AG042489 · NIA · YALE UNIVERSITY · PI SHAW, ALBERT C · 2012 to 2022
$1.8M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS U19 AI089992NIA NIH HHS K24 AG042489NIA NIH HHS R01 AG055362NIA NIH HHS R01 AG056728
6 · The paper itself

Abstract

Alterations in the components of the immune system occur with aging. The introduction of combination antiretroviral therapy (ART) has dramatically improved life expectancy in human immunodeficiency virus (HIV) infected individuals by suppressing viral replication and increasing CD4

Indexed as

HIV InfectionsAgedAgingCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansLeukocytes, MononuclearPerforinReceptors, Interleukin-7ViremiaPerforinReceptors, Interleukin-7agegene expressionhumanhuman immunodeficiency virus (HIV)T cells

Identifiers

PMID36036630
PMCPMC9577958
OpenAlexW4293446079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.