Evidence map›Paper›PMID 36036455›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2022

Skeletal muscle blood flow during exercise is reduced in a rat model of pulmonary hypertension.

Gary Marshall Long, Ashley D Troutman, Derrick A Gray, Amanda J Fisher, Tim Lahm, Andrew R Coggan, Mary Beth Brown

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Effect of pre-exercise dietary nitrate on skeletal muscle blood flow in a rat model of pulmonary hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Gary Marshall LongDepartment of Kinesiology, University of Indianapolis, Indianapolis, Indiana.ORCID 0000-0001-7682-3693
Ashley D TroutmanDepartment of Kinesiology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.
Derrick A GrayDepartment of Kinesiology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.
Amanda J FisherDepartment of Kinesiology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.
Tim LahmPulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colorado.ORCID 0000-0003-0007-6606
Andrew R CogganDepartment of Kinesiology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.ORCID 0000-0002-7723-8872
Mary Beth BrownDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington.ORCID 0000-0003-4229-6877
Indiana University – Purdue University Indianapolis · USNational Jewish Health · USUniversity of Indianapolis · USUniversity of Washington · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Mechanisms of Right Ventricle Adaptation to Pulmonary HypertensionR01HL144727 · NHLBI · NATIONAL JEWISH HEALTH · PI Tim Lahm · 2019 to 2026
$4.7M
Maximizing benefit and minimizing detriment of exercise for pulmonary hypertensionR15HL121661 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROWN, MARY BETH · 2015 to 2015
$455k
BLRD VA I01 BX002042NHLBI NIH HHS R01 HL144727NHLBI NIH HHS R15 HL121661NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is characterized by exercise intolerance. Muscle blood flow may be reduced during exercise in PAH; however, this has not been directly measured. Therefore, we investigated blood flow during exercise in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH). Male Sprague-Dawley rats (∼200 g) were injected with 60 mg/kg MCT (MCT,

Indexed as

Hypertension, PulmonaryAnimalsDisease Models, AnimalHemodynamicsLactatesMaleMonocrotalineMuscle, SkeletalPulmonary ArteryRatsRats, Sprague-DawleyLactatesMonocrotalineblood flowexercisePAHpulmonary hypertensionskeletal muscle

Identifiers

PMID36036455
PMCPMC9602702
OpenAlexW4293434037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.