ArticleThe Journal of comparative neurology2022
Neuropeptide S (NPS) neurons: Parabrachial identity and novel distributions.
Article in The Journal of comparative neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Neuropeptide S modulation of learning and memory: a systematic review.Behavioral and brain functions : BBF · 2026Pooled it
- Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract.The Journal of comparative neurology · 2026Article
- ParabrachialProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Intersectional expression ofAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Nps-Expressing Neurons Receive Extensive Input From Auditory Brainstem Nuclei.The Journal of comparative neurology · 2026Article
- Conserved sleep disturbances in FOXP1 syndrome originate from developmental dysregulation of peptidergic signaling.The Journal of clinical investigation · 2026Article
- AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.The Journal of comparative neurology · 2026Article
- Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- NPS neurons receive extensive input from auditory brainstem nuclei.bioRxiv : the preprint server for biology · 2025Article
- Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system.Pharmacological reviews · 2025Review
- ParabrachialiScience · 2025Article
- Efferent projections of Nps-expressing neurons in the parabrachial region.The Journal of comparative neurology · 2024Article
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.Nature communications · 2024Article
- Diverse roles of pontine NPS-expressing neurons in sleep regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A cluster of neuropeptide S neurons regulates breathing and arousal.Current biology : CB · 2023Article
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.bioRxiv : the preprint server for biology · 2023Article
- Neuropeptide S (NPS) neurons: Parabrachial identity and novel distributions.The Journal of comparative neurology · 2022Article
- Molecular and anatomical characterization of parabrachial neurons and their axonal projections.eLife · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Neuropeptide S (NPS) increases wakefulness. A small number of neurons in the brainstem express Nps. These neurons are located in or near the parabrachial nucleus (PB), but we know very little about their ontogeny, connectivity, and function. To identify Nps-expressing neurons within the molecular framework of the PB region, we used in situ hybridization, immunofluorescence, and Cre-reporter labeling in mice. The primary concentration of Nps-expressing neurons borders the lateral lemniscus at far-rostral levels of the lateral PB. Caudal to this main cluster, Nps-expressing neurons scatter through the PB and form a secondary concentration medial to the locus coeruleus (LC). Most Nps-expressing neurons in the PB region are Atoh1-derived, Foxp2-expressing, and mutually exclusive with neurons expressing Calca or Lmx1b. Among Foxp2-expressing PB neurons, those expressing Nps are distinct from intermingled subsets expressing Cck or Pdyn. Examining Nps Cre-reporter expression throughout the brain identified novel populations of neurons in the nucleus incertus, anterior hypothalamus, and lateral habenula. This information will help focus experimental questions about the connectivity and function of NPS neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.