SynthesisEuropean geriatric medicine2022
The association between metabolic syndrome and presence of frailty: a systematic review and meta-analysis.
Synthesis in European geriatric medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- The Application of Metabolomics in Frailty: Trends, Challenges, and Future Directions.Metabolites · 2026Review
- Longitudinal changes in frailty, insulin resistance and incident cardiovascular-kidney- metabolic syndrome progression in middle-aged and older adults: evidence from CHARLS.Diabetology & metabolic syndrome · 2025Article
- Frailty Syndrome and Cardiovascular Diseases in Older People.Healthcare (Basel, Switzerland) · 2025Article
- Prevalence and coexistence of locomotive syndrome with reduced mobility and metabolic syndrome: a cross-sectional study of 35,059 Japanese adults.Scientific reports · 2025Article
- Comorbidity burden and outcomes of endoscopic ultrasound-guided treatment of pancreatic fluid collections: Multicenter study with nationwide data-based validation.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025Article
- Correlation of alternative healthy eating index with risk of frailty among metabolic syndrome individuals: a cross-sectional study.Aging clinical and experimental research · 2025Article
- The relationship between frailty and major adverse cardiovascular and cerebrovascular events in Chinese older adults: the mediating effect of lipid accumulation products.Archives of public health = Archives belges de sante publique · 2025Article
- The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands: a Lifelines cohort study.Immunity & ageing : I & A · 2024Article
- Association of platelet-to-HDL cholesterol ratio with frailty and all-cause mortality.Lipids in health and disease · 2024Article
- Longitudinal analysis on inflammatory markers and frailty progression: based on the English longitudinal study of aging.European geriatric medicine · 2024Article
- Association of metabolic syndrome and frailty with postoperative complications in older gastric cancer patients: A body composition perspective.Cancer medicine · 2024Observational
- Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study.Cardiovascular diabetology · 2024Article
- Frailty and Cardiovascular Health.Journal of the American Heart Association · 2024Review
- The Association between Circadian Syndrome and Frailty in US adults: a cross-sectional study of NHANES Data from 2007 to 2018.Aging clinical and experimental research · 2024Article
- Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life.GeroScience · 2024Article
- Association between physical frailty, circadian syndrome and cardiovascular disease among middle-aged and older adults: a longitudinal study.BMC geriatrics · 2024Article
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- Effect of overweight/obesity and metabolic syndrome on frailty in middle-aged and older Japanese adults.Obesity science & practice · 2024Article
- The Role of Surgical Prehabilitation During the COVID-19 Pandemic and Beyond.Physical medicine and rehabilitation clinics of North America · 2023Review
- Bidirectional Relationship Between Circadian Rhythm and Frailty.Nature and science of sleep · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty represents a progressive deterioration in multi-system of the body and could increase vulnerability to stressors. Recently, several studies found that metabolic syndrome was significantly associated with frailty and emphasized its role in assessing and preventing frailty. However, these conclusions are controversial. We conducted this systematic review and meta-analysis to evaluate the association between metabolic syndrome and frailty.
methodsDatabases including Pubmed, Embase, Web of Science, CINAHL Complete, China National Knowledge Infrastructure (CNKI) and Wanfang Data Knowledge Service Platform were searched for studies on the association between metabolic syndrome and frailty, from inception to 17th June 2022. Two researchers independently screened the literature, extracted the data and evaluated the quality. Stata/SE 15.0 software was used to perform the statistical analysis.
resultsEleven studies were included in this review and eight studies were included in the meta-analysis, involving one prospective cohort studies and ten cross-sectional studies with 12,640 participants. The pooled results indicated that metabolic syndrome was significantly associated with frailty (OR = 1.82, 95% CI = 1.46-2.27) with a low heterogeneity (I
conclusionsThe findings of this systematic review and meta-analysis suggested that metabolic syndrome could be significantly associated with the presence of frailly. Future studies need to further consider the effects of measurement tools, age and specific disease status in this association. Furthermore, the casual relationship between them is to be determined.
Indexed as
Identifiers
36036343What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.