Evidence map›Paper›PMID 36036310›Full record

ArticleJournal of cancer research and clinical oncology2023

Association between oral cavity cancer and metabolic syndrome.

Gang Won Choi, Hyeon-Kyoung Cheong, Soo Young Choi, Young Chan Lee, In-Hwan Oh, Young-Gyu Eun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Increasing number of non-risk oral cancer patients in Korea: obesity and oral cancer.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2026
    Article
  5. Impact of statin use in head and neck cancer: a nested case-control study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Gang Won Choi *Department of Otolaryngology Head and Neck Surgery, School of Medicine, Kyung Hee University, Kyung Hee University Medical Center, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 02447, South Korea.
Hyeon-Kyoung Cheong *Department of Internal Medicine, School of Medicine, Korea University, Ansan, South Korea.
Soo Young ChoiDepartment of Otolaryngology Head and Neck Surgery, School of Medicine, Kyung Hee University, Kyung Hee University Medical Center, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 02447, South Korea.
Young Chan LeeDepartment of Otolaryngology Head and Neck Surgery, School of Medicine, Kyung Hee University, Kyung Hee University Medical Center, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 02447, South Korea.
In-Hwan Oh *Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea.
Young-Gyu Eun *Department of Otolaryngology Head and Neck Surgery, School of Medicine, Kyung Hee University, Kyung Hee University Medical Center, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 02447, South Korea. ygeun@hanmail.net.
Kyung Hee University Medical Center · KRKorea University · KRKyung Hee University · KR

Funding

Korea goverment 2020R1A5A2019413Ministry of Health & Welfare, Republic of Korea HI20C1205
6 · The paper itself

Abstract

purposeFew studies have been conducted on the association between oral cavity cancer and metabolic diseases. This study aimed to investigate the relationship between oral cavity cancer and metabolic diseases.

methodsThis cohort study used the database of the Korean National Health Insurance Service, which contains medical data of 97% of the Korean population. Oral cavity cancer occurred in a total of 2718 patients. Metabolic syndrome was defined according to IDF criteria. The Cox proportional hazard regression model was used.

resultsThe HR for oral cavity cancer in patients with metabolic syndrome was 1.113(95% CI 1.006-1.232), which was significantly higher than that in normal patients, especially in males (p = 0.0386). When the number of metabolic syndrome factors was ≥ 3, the HR of oral cavity cancer was 1.191(95% CI 1.026-1.383), which was significantly higher than that of 0 metabolic syndrome factors, especially in males (p = 0.0218). When the number of metabolic syndrome factors was ≥ 3, the HR for oral cavity cancer was 1.439(95% CI 1.066-1.942), which was significantly higher than that of 0 metabolic syndrome factors, especially in males aged < 50 years (p = 0.0173).

conclusionMetabolic syndrome increases the risk of oral cavity cancer only in males. In addition, the incidence of oral cavity cancer increased as the number of factors constituting metabolic syndrome increased, only in young males aged < 50 years. Thus, metabolic syndrome is an important risk factor for oral cavity cancer, particularly in young males.

Indexed as

Metabolic DiseasesMetabolic SyndromeMouth NeoplasmsCohort StudiesHumansIncidenceMaleRisk FactorsDiabetesDyslipidemiaHypertensionMetabolic syndromeObesityOral cavity cancer

Identifiers

PMID36036310
PMCPMC11797565
OpenAlexW4293439882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.